Thalidomide was introduced as a sedative drug, immunomodulatory agent and also is investigated for treating symptoms of many cancers. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1. Thalidomide Chemical Structure CAS No. 50-35-1 Size ...
Structure–activity-relationshipSemi-empirical AM1 methodDensity functional theoryThe structural and electronic properties of the thalidomide molecule have been investigated theoretically by performing semi-empirical molecular orbital (AM1) and density functional theory calculations. The geometry of the molecule...
Crystal and molecular structure of thalidomide, N-(α-glutarimido)-phthalimide Journal of the Chemical Society B: Physical OrganicPub Date : 1971, DOI:10.1039/j29710001073 F. H. Allen , James Trotter Crystals of theN-(α-glutarimido)-derivative of phthalimide (Thalidomide), C13H10N2O4, are ...
This pipeline has been applied to the latest version of the ChEMBL database as well as uncurated datasets from other sources to test the robustness of the process and to identify common issues in database molecular structures. Conclusion All the components of the structure pipeline have been ...
et al. Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling. Science 296, 1886–1889 (2002). CAS PubMed Google Scholar Fischer, E. S. et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature 512, 49–53 (2014). CAS Pub...
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S. et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature 512, 49–53 (2014). Article CAS PubMed PubMed Central Google Scholar Winter, G. E. et al. Systems-pharmacology dissection of a drug synergy in imatinib-resistant CML. Nat. Chem. Biol. 8, ...
Results show that each of the investigated proteasome inhibitors induced identical proteasome-inhibitor-specific ubiquitin-positive immunostaining and nuclear displacement in PC12 cells. Other agents--such as paclitaxel, cisplatin, and thalidomide, which cause neuropathy by other mechanisms--did not cause ...
Crystal Structure Density Electrical Conductivity Eletronegativity Freezing Point Heat of Vaporization Ionic Radius Ionization Potential Mass Average Melting Point Element Name Series Symbol Thermal Conductivity Year of Discovery HazMat Household Guide to Handling Household Chemicals The Dangers of La...
E. et al. Crystal structure of the SALL4–pomalidomide–cereblon–DDB1 complex. Nat. Struct. Mol. Biol. 27, 319–322 (2020). Article CAS PubMed Google Scholar Fink, E. C. et al. CrbnI391V is sufficient to confer in vivo sensitivity to thalidomide and its derivatives in mice. Blood...