From a practical chemical point of view, acrylates, cyanoacrylates and (meth)acrylates, cephalosporins, and parabens have been grouped together.doi:10.1007/978-3-642-02035-3_199J.-P. LepoittevinC.J. Le CozLe Coz CJ, Lepoittevin JP. Dictionary of contact allergens: chemical structures, ...
or loss on the enzyme gene; (2) efflux pump: the intracellular concentration of antibiotics is reduced due to the change of cell membrane structure; (3) antibiotic inactivation: antibiotic molecules are directly deactivated; or (4) target modification: the action sites of antibiotic are modified....
Cefepime has a pharmacokinetic disposition similar to that of other renally eliminated cephalosporins, with a half-life of approximately 2 hours. Cefepime has demonstrated clinical efficacy against a variety of infections, including urinary tract infections, pneumonia, and skin and skin structure infections...
Further, we describe the resulting chemical genetic interaction networks and highlight the prominent and overlapping target sets that restore MRSA susceptibility to penicillin, cephalosporins, and carbapenems. Pharmacological validation of this approach is the potent synergy between a known inhibitor to a ...
major drug groups in the “Antiinfectives for systemic use” main group, antibacterial groups in the “Antibacterials for systemic use” group. In the cases of (1) different batches of the exact same chemical structure and (2) different salt forms of same compound (identified by the same ...
Ceftriaxone for injection, like other cephalosporins, has no activity against Chlamydia trachomatis. Therefore, when cephalosporins are used in the treatment of patients with pelvic inflammatory disease and Chlamydia trachomatis is one of the suspected pathogens, appropriate ...
reactivity/stability of thioester and structure of the AAs in the ring/near the ligation site137,138,139. In addition, the findings of AML have established that templating effects can assist the rate of the intramolecular reaction across a range of ring sizes75. This combination of factors can...
(I) may be used either in its free form or as any of salts pharmacologically and pharmaceutically acceptable in the field of cephalosporins and penicillins in general. For example, the 4-carboxyl group may form a salt, e.g. with a nontoxic alkali metal cation such as sodium or potassium,...
It has been found by the present inventors that a novel antibiotic is produced by a microorganism belonging to the genus Streptomyces and is accumulated in the culture broth; that the new antibiotic has cephalosporin-type chemical structure and is useful, e.g., in the treatment of mammals inclu...
chloramphenicol, miconazole, quinolones such as oxolinic acid, norfloxacin, nalidixic acid, pefloxacin, enoxacin and ciprofloxacin, penicillins such as oxacillin and pipracil, nonoxynol 9, fusidic acid, cephalosporins, and combinations thereof. In addition, antimicrobial proteins and peptides such as bo...