(79)393〉. The X-ray crystal structure of a number of β-lactams has now been determined, and the degree of reactivity and antibacterial activity has been correlated with a decrease in amide resonance due to strain imposed by the bicyclic system〈74JMC523〉. The unusual reactivity of ...
the structure of wild-type NDM-1 (tan, PDB ID: 3SPU) with that of NDM-1 K224R/G232A/N233Q (dark cyan) for residues 231 to 237. A large change in the conformation of the 231–237 region of the NDM-1 K224R/G232A/N233Q mutant is seen versus the structure of wild-type NDM-1...
The optically active compounds obtained in the present invention are assumed to have the absolute structure represented by the general formula (I-1), that is (6R, 7S), from various properties, strong antimicrobial activity of the acyl compounds as compared with the corresponding optically inactive ...
(Fig. 21.1). The cephem nucleus is chemically distinct from the penicillin nucleus, which contains a five-member thiazolidine ring. Basic structure numbering of the cephalosporin ring system begins within the dihydrothiazine ring at the sulfur moiety. The starting material used as the nucleus for ...