Most drugs are subject to some form of chemical decomposition, particularly when formulated as liquid dosage forms. Some of the consequences of degradation are that the aged medicinal preparation no longer has the desired pharmacological potency. It may also exhibit physical manifestations of ...
Chemical stability of pharmaceuticals : a handbook for pharmacists L. Amidon,and L.Kennon,"ChemicalStability of Pharmaceuticals: A Handbook for Pharmacists," Wiley, New York, N.Y., 1979,pp. 195-200... Connors,A Kenneth,Kenneth A.Connors ... [et al - Wiley 被引量: 97发表: 1979年 Chemi...
At pH 7.4, the stability of Valthiazole-acyclovir was remarkable. At this pH, Val-thiazole-acyclovir showed stability higher than that of valacyclovir (the first effective prodrug of acyclovir). 展开 关键词: amino acids thiazole antiviral drugs hplc prodrugs ...
It is useful to establish the rate of crucial stability reactions. If the half-life is on the order of minutes or hours, then there will be an effect on the ‘pharmacological timescale’ and this affects activity in vivo. If the half-life is on the order of months or years, then ther...
neither of which was standardised. Military interest in ricin grew during World War II when field tests on the effectiveness of converting ricin to a combat state in aerosol form were conducted. Its introduction into ordnance was limited by its low stability and challenges in industrial production ...
Stability test of drugs|药品的稳定性试验 基本信息更多信息 中文名称:药品的稳定性试验 中文同义词:药品的稳定性试验 英文名称:Stability test of drugs 英文同义词:Stability test of drugs CAS号: 分子式: 分子量:0 EINECS号: 信息错误报告 您的Email: ...
Transformations of bioactive peptides in the presence of sugars—Characterization and stability studies of the adducts generated via the Maillard reaction Glycation of biomolecules, such as proteins, peptide hormones, nucleic acids, and lipids, may be a major contributor to the pathological manifestations...
The organic drugs are chemical moiety used for therapeutic effects but the targeting of this drug moiety are difficult due to presence of pharmaceutical/ physiological barrier so there is need of change in physicochemical properties of drug.For targeting of drug many novel approaches used such as ...
By placing artificial metalloenzymes (ArMs) in phase-separated sanctuary regions formed by their protein scaffolds inEscherichia coli, we developed various whole-cell catalysts with high power and catalytic stability. Such whole cells with sheltered ArMs achieved substantially higher turnover numbers per...
Succinimidyl trans-4-(maleimidylmethyl)cyclohexane-1-carboxylate (SMCC) is our reagent of choice for introducing thiol-reactive groups at amine sites because of the superior chemical stability of its maleimide and its ease of use (Figure 5.2.5). Figure ...