J Nève - 《Journal of Trace Elements in Medicine & Biology》 被引量: 363发表: 1995年 Separation of Selenium-Containing Proteins in Human and Mouse Plasma Using Tandem High-Performance Liquid Chromatography Columns Coupled with Inductively C... An analytical method that uses two different high-per...
Versatile protein recognition by the encoded display of multiple chemical elements on a constant macrocyclic scaffold. Nat. Chem. 10, 441-448 (2018)... Yizhou,Li,Roberto,... - 《Nature Chemistry》 被引量: 2发表: 2018年 Second-generation DNA-encoded multiple display on a constant macrocyclic...
the encoded display of multiple chemical elements on a constant scaffold enabled practical applications, such as fluorescence microscopy procedures or the selective in vivo delivery of payloads to tumours. Furthermore, the versatile structure of the scaffold facilitated the generation of protein-specific ...
an amino acid sequence of each protein is vectorized; a vector containing elements of the vector derived from each protein and elements of the vector derived from each chemical paired with the protein is created; and a support vector machine (SVM) is applied to this vector and trained to lear...
Here we show, using atomic-scale quantitative imaging and correlative spectroscopies, that the nanoscale crystallites of hydroxylapatite (Ca5(PO4)3(OH)), which are the fundamental building blocks of enamel, comprise two nanometric layers enriched in magnesium flanking a core rich in sodium, ...
Nucleic acid and/or protein macromolecule based nanomedicines present an exciting avenue in medical care. Within the last three decades almost three-thousand gene therapy clinical trials have been performed, and at least nine gene therapy products reached medical market authorization, see [1] and http...
According to convention, if the three diagonal elements in Eq. (9) are arranged in a decreasing numerical order, these are called δ11 ‚ δ22 ‚ and δ33 (δ11 > δ22 > δ33), respectively. The isotropic chemical shift δiso is defined as the average of the tensor trace: (10)...
Nitrogen is one of the most interesting of all chemical elements. It is not a very active element. It combines with relatively few other elements at room temperature. Yet, the compounds of nitrogen are enormously important both in living organisms and in industrial applications. Five of the top...
Protein labeling approaches are important to study proteins in living cells, and genome editing tools make it possible to tag endogenous proteins to address the concerns associated with overexpression. Here we established RNA editing-mediated noncanonica
Continuous evolution can generate biomolecules for synthetic biology and enable evolutionary investigation. The orthogonal DNA replication system (OrthoRep) in yeast can efficiently mutate long DNA fragments in an easy-to-operate manner. However, such a