关键词:乳腺癌;乳腺癌家族史阳性:临床特点;预后袁同学 天津医科大学硕士学位论文TheanalysisofCI皿K2genemutationandtheclinicalretrospectivestudyonfhmilialbreastcancerAbstractPartITheanalysisofCHEK2genemutationinbreastcancerfAmilies0bjective:TheaimofmestudywastoexplorethepreValence,the“hotspots”ofCHEK2.aIldwhe血er...
MutationCHEK2 gene is known as a tumor suppressor gene in breast cancer (BC), which plays a role in DNA repair. The germ line mutations in CEHK2 have been associated with different types of cancer. The present study was aimed at studying the association between CHEK2 mutations and BC. ...
CHEK2genemutationsarerelatedtopathologicfeaturesandprognosisofbreastcancer.SothetestofCHEK2genemutationsmaybehascertainindicationroleinthetreatmentofbreastcancer.However,theroleofCHEK2genemutationsinChinesepopulationstillneedsfurtherresearch.【Keywords】 Gene;Mutation;Breastneoplasms;CHEK2 细胞周期检查点激酶2(cell ...
CHEK2基因突变初探及家族性乳腺癌临床回顾性研究
Wokolowczyk D, Matuszewski M, Sun P, Lubinski J, Narod SA. Cancer risks in first-degree relatives of CHEK2 mutation carriers: effects of mutation type and cancer site in proband. Br J Cancer. 2009 May 5;100(9):1508-12. doi: 10.1038/sj.bjc.6605038. PMID: 19401704; PMCID: PMC269442...
These interactions suggest that CHEK2 may also play a role in breast cancer [14]. Germline CHEK2 mutations are associated with breast cancer in different populations. For example, heterozygosity for the well-studied c.1100delC mutation, present in 1.4% of the Finnish population and in 0.2% ...
The CHEK2 1100delC mutation identifies families with a hereditary breast and colorectal cancer phenotype. Am J Hum Genet. 2003;72(5):1308-1314. doi:10.1086/375121PubMedGoogle ScholarCrossref 16. CHEK2 Breast Cancer Case-Control Consortium. CHEK2*1100delC and susceptibility to breast ...
TNM stage and p53 status.Conclusion Detection of p-CHEK2Thr68 protein expression by immunohistochemistrymay help to investigate the biological behavior of invasive breast cancer and to develop individualized treatment strategy.%目的 研究在浸润性乳腺癌组织中磷酸化细胞周期检查点激酶2(p-CHEK2Thr68)的表达...
This is one of the few examples of a genetic factor that influences long-term prognosis being documented in an extensive series of women with breast cancer. 展开 关键词: Humans Breast Neoplasms Neoplasms, Second Primary Case-Control Studies Prospective Studies Genotype Germ-Line Mutation Middle ...
Objective To investigate the prevalence of CHEK2 c.1100delC mutation among non-BRCA1/BRCA2 familial/early-onset breast cancer patients in Shanghai. Methods One hundred and fourteen non-BRCA1/BRCA2 hereditary breast cancer patients were analyzed, among whom 76 cases had at least one first-degree...