A common feature of TTFL proteins, particularly those in the negative arm, is that the proteins are enriched for Intrinsically Disordered Regions (IDRs)5. IDRs are protein regions characterized by an inability to adopt a stable tertiary structure; instead, IDRs exist in a collection of interconver...
Net charge of -3-3 at pH 7 and with the amino acids arginine15 or arginine15-alanine17 in the binding region; serine protease inhibitorsdoi:US20030096752 A1The present invention relates to aprotinin variants having improved enzyme-inhibitory, immunological and pharmacokinetic properties and their ...
What is the net charge of the tripeptide Gly-Ala-Tyr at pH 13.9? What is the charge on the tetrapeptide lys-lys-his-glu at a pH of 7? A. 0. B. +1. C. +2. D. -1. A) what is the ph of 3.3 � 10 ? 3 M H C l ? B) What is the pH of 8...
specific to lysine or if other cationic peptides would also form coacervates together with the R3C ribozyme system. For arginine homopeptides (Rn) (Fig.1c), we found that an 18-residue arginine homopeptide formed coacervates at higher a.a./nt ratios than its homolysine counterpart. Furtherm...
Here, we investigate the role of intrinsically disordered mixed-charge domains (MCDs) in nuclear speckle condensation. Proteins composed exclusively of arginine-aspartic acid dipeptide repeats undergo length-dependent condensation and speckle incorporation. Substituting arginine with lysine in synthetic and ...
of arginyl-tRNA formation in fraction II, yet almost completely inhibited arginine transfer from arginyl-tRNA to reduced/carboxymethylated bovine serum albumin... NS Klemperer,CM Pickart - 《Journal of Biological Chemistry》 被引量: 119发表: 1989年 Reaction of xanthine oxidase-derived oxidants with...
substituting charged amino acids with non-charged ones reduced the nucleolar accumulation in proportion to the charge reduction, and nucleolar accumulation efficiency was strongly correlated with the predicted charge of the tested sequences; and (iii) sequences containing only lysine or arginine residues...
What is the overall charge of the tripeptide SGR (serine, glycine, arginine) below the pH of 1? Given the following peptide: Val-Met-Ser-Gly-Glu-Ser-Asp-His-Lys-Cys-Tyr-Leu a) What is the pI? b) What is the net charge at pH 7.0? c) What is the net charge at pH 4.0? What...
Although proteins have attractive features as biopharmaceuticals, the difficulty in delivering them into the cell interior limits their applicability. Lipid nanoparticles (LNPs) are a promising class of delivery vehicles. When designing a protein deliver
9 Self-aggregation of the pre-BCR induced by electrostatic interaction between themselves has been proposed to explain the generation of this tonic signal. Mutation of seven evolutionarily conserved, positively charged arginine residues in the N-terminal portion of λ5 chain, a component of the ...