Non-additive interactions between mutations occur extensively and also change across conditions, making genetic prediction a difficult challenge. To better understand the plasticity of genetic interactions (epistasis), we combine mutations in a single protein performing a single function (a transcriptional r...
A Genetic Polymorphism in the Regulatory Sequences of HumanCYP2E1:Association with Increased Chlorzoxazone Hydroxylation in the Presence of Obesity and Eth... To pursue the hypothesis that differences in the regulatory region ofCYP2E1are partially responsible for the intersubject variation inin vivoCYP...
DNA sequencing analyses also revealed reduced numbers of distinct sequence variants in the three genes from 2006‒2007 to 2013‒2016:msp-1, from 32 to 23 (about 28% decline);msp-2from 29 to 21 (about 28% decline), andmsp-3from 11 to 3 (about 72% decline). The present data ...
Changes in the molecular structure of the gene mutations mean genes, the DNA nucleotides in the gene sequence has changed, resulting in a change in the genetic information. Gene mutation frequency is low, but can produce new genes, biological evolution has important significance. ...
structurally similar to ESR1 and ESR212but whose ligands are unknown. ESRRA also has DNA sequence homology to the estrogen receptor and can be activated by phytoestrogens (i.e. genistein)13. These receptors play pivotal roles in metabolism, insulin resistance, NAFLD, and mitochondrial function12. ...
Moreover, there were some genomic sequence changes including parental bands elimination and novel bands emergence in the ILs. The average Nei's gene diversity (He) was 0.296, which was higher than that of cultivated rice. It suggested that interspecific hybridization and gene introgression could ...
Demographic changes in Chile during the period 1960-1974 are presented which illustrate the theory that massive use of birth control will affect the microevolution of the population. The sequence of events which fit the sex-linked genetic theory are as follows: 1) birth control results in low pa...
Genetic variants in RNA polymerase II that reduced its speed in worms5 and flies6 increased their lifespan. Similarly, reducing the speed of RNA polymerase II by overexpressing histone components, to counter age-associated changes in nucleosome positioning, also extended lifespan in flies and the ...
Apc mutations were detected in PhIP- and IQ-induced rat colon tumors, with incidences of 50% (4/8) and 15% (2/13), respectively. All five mutations detected in the four PhIP-induced tumors consisted of a guanine deletion from the 5′-GGGA-3′ sequence, in contrast with T to C and...
Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is,...