与其它过渡金属(如钯、镍等)参与的偶联反应相比,此类反应的催化剂铜盐价格便宜；反应条件温和、不需要复杂配体、操作简便、在空气氛围中搅拌就能顺利进行；该反应有一个缺点，就是反应时间一般都比较长，大概要24-72小时。反应示例 1.Chan-Evans-Lam反应合成咔唑化合物 反应示例 2.芳基硼酸频哪醇酯和...
Chan-Evans-Lam偶联反应研究进展 优先出版 下载积分: 1500 内容提示: 有机化学 Chinese Journal of Organic Chemistry REVIEW * E-mail: moeastlight@mailbox.gxnu.edu.cn Received ; revised ; published online . Project supported by the National Natural Science Foundation of China (21562005, 21602037); ...
Chan-Lam-Evans偶联反应(Chan-Lam-Evans Coupling) 概要 该反应是苯胺・硫酚・酚与芳基硼酸的交叉偶联反应。铜能促进该反应的进行。与Goldberg反应与Buchwald-Hartwig反应中使用卤代芳烃为底物有所不同的是,该反应是使用芳基硼酸作为底物的偶联反应。 所用试剂都是简单易得的,而反应在室温搅拌就可以进行...
Cross-couplingDirect functionalization of protected histidines with arylboronic acids is described under ChanLamEvans conditions to give the corresponding N()-arylhistidines in moderate to good yields (12 examples, up to 83% yield) under mild conditions.doi:10.1002/ejoc.201000591...
摘要: Chan-Evans-Lam偶联反应在20世纪90年代被发现以后经历了突飞猛进的发展.Chan-Evans-Lam偶联反应作为一类条件温和、高效、官能团兼容性好的偶联方法,不仅被广泛地应用于各种碳-杂键、碳-碳键的形成反应中,也成功地应用于复杂天然产物的全合成中.综述了近5年来Chan-Evans-Lam偶联反应在有机... 查看全部>> ...
Those BPin groups were further reacted with various nucleophiles in the presence of a copper(II) source in the conditions of the aerobic Chan-Lam-Evans coupling. The resulting materials were characterized by TGA, XPS and ToF-SIMS. This route is efficient, reliable and among the scarce ...
有关Chan-Evans-Lam偶联反应求助？请问楼主用什么条件做出来了吗 最近也在做类似的都不反应 我需要产物...
Copper-mediated Chan-Evans-Lam N-arylation of 5-methylene-4-aryl1,5-dihydro-2H-pyrrol-2-one derivatives 来自 国家科技图书文献中心 喜欢 0 阅读量: 44 作者:Almohaywi,Basmah,Iskander,George,Tsz,Tin,Bhadbhade,Mohan,Black,David 摘要: A simple and efficient procedure for the synthesis 关键词: ...
Copper catalyzed N-arylation of amidines with aryl boronic acids and one-pot synthesis of benzimidazoles by a chan-lam-evans N-arylation and C-h activation/c-N bond forming process. Li Jihui,Bénard Sébastien,Neuville Luc,Zhu Jieping. Organic Letters . 2012...
An unprecedented, simple and general protocol for the selective formation of C–N bonds was developed by using cheap and easily available Cu(OAc)2 as catalyst for the Cu(II)-catalysed Chan–Evans–Lam reaction in Deep Eutectic Solvents (DESs) as sustainable reaction media. The meticulous ...