与其它过渡金属(如钯、镍等)参与的偶联反应相比,此类反应的催化剂铜盐价格便宜；反应条件温和、不需要复杂配体、操作简便、在空气氛围中搅拌就能顺利进行；该反应有一个缺点，就是反应时间一般都比较长，大概要24-72小时。反应示例 1.Chan-Evans-Lam反应合成咔唑化合物 反应示例 2.芳基硼酸频哪醇酯和芳香胺,烷基胺的C−N键偶联反应
Chan-Lam-Evans偶联反应(Chan-Lam-Evans Coupling) 概要 该反应是苯胺・硫酚・酚与芳基硼酸的交叉偶联反应。铜能促进该反应的进行。与Goldberg反应与Buchwald-Hartwig反应中使用卤代芳烃为底物有所不同的是,该反应是使用芳基硼酸作为底物的偶联反应。 所用试剂都是简单易得的,而反应在室温搅拌就可以进行...
Chan-Evans-Lam偶联反应研究进展 优先出版 下载积分: 1500 内容提示: 有机化学 Chinese Journal of Organic Chemistry REVIEW * E-mail: moeastlight@mailbox.gxnu.edu.cn Received ; revised ; published online . Project supported by the National Natural Science Foundation of China (21562005, 21602037); ...
Direct N-arylation of protected histidines (I) is readily achieved using arylboronic acids (II) under mild Chan—Lam—Evans conditions.doi:10.1002/chin.201048196Christophe DalZottoInst. Charles Gerhardt Montpellier, Ec. Natl. Super. Chim., F‐34296 Montpellier, Fr.Julien Michaux...
摘要: Chan-Evans-Lam偶联反应在20世纪90年代被发现以后经历了突飞猛进的发展.Chan-Evans-Lam偶联反应作为一类条件温和、高效、官能团兼容性好的偶联方法,不仅被广泛地应用于各种碳-杂键、碳-碳键的形成反应中,也成功地应用于复杂天然产物的全合成中.综述了近5年来Chan-Evans-Lam偶联反应在有机... 查看全部>> ...
Those BPin groups were further reacted with various nucleophiles in the presence of a copper(II) source in the conditions of the aerobic Chan-Lam-Evans coupling. The resulting materials were characterized by TGA, XPS and ToF-SIMS. This route is efficient, reliable and among the scarce ...
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They were competent catalysts for Chan–Evans–Lam couplings with phenylboronic acid, without any indication of side reactions such as deboration or aryl homocoupling. The complexes were active in undried methanol, without addition of base, ligand, or molecular sieves. Aniline, n-octylamine, and ...
Chan—Lam—Evans reactionN-arylationboronic acidscopper catalysisbispidinesX-ray diffraction.The N -arylation of N -Boc-bispidine with arylboronic acids was accomplished under the copper-catalyzed Chan—Lam—Evans reaction conditions. The reaction products were characterized by NMR spectroscopy and X-...
Various unreported N -aryl phosphinamides and phosphonamides were successfully prepared through Chan-Evans-Lam reaction with high efficiency (up to 88% yields) and good functional groups tolerance (30 examples) in the absence of any ligands or co-catalysts....