In the present study, we describe a polymerase chain reaction (PCR)-based enzyme-linked immunosorbent assay for the detection of malaria infection. The target region of the 18S ribosomal DNA is amplified by a PCR using an 18S rRNA, genus-specific, biotinylated (5') and an unlabeled primer (...
Hemoglobin Gamma Chain refers to one of the non-alpha globin chains that, in combination with alpha globin molecules, forms the protein tetramer hemoglobin. At birth, the predominant hemoglobin is HgbF, which consists of two alpha and two gamma chains (α2γ2). AI generated definition based on...
This condition results from the pooling of large quantities of blood in the spleen and leads to shock with profound anemia. Aplastic crisis results when the normal brisk reticulocytosis associated with SCD is suppressed, usually as a result of an intercurrent viral infection with parvovirus B19....
However, due to the low throughput nature 1Department of Biology, South University of Science and Technology of China, Shenzhen 518055, China. 2State Key Laboratory of Respiratory Disease, Center for Infection and Immunity, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences,...
Thus, PfHRP2 RDT is practically unable to differentiate between past and current malaria infection. Similarly, false negative has been noted due to P. falciparum histidine-rich protein 2 (pfhrp2) gene deletions [11]. Therefore, there is a high probability of underdiagnosis, overdiagnosis, and ...