Flow diagram for two compartment models of malaria transmission.Karina LaneriAnindya BhadraEdward L. IonidesMenno BoumaRamesh C. DhimanRajpal S. YadavMercedes Pascual
A stochastic transmission model for malaria was developed that follows previous77,78,79extensions of the compartmental SEIR model. The diagram illustrating its compartmental structure for the human population and for the phenomenological representation of the mosquito is shown in Fig.2A. Alternative formul...
Ronald Ross in his first mathematical model of malaria used the word "pathometry" to mean "quantitative study of a disease either in the individual or in the community" [36]. Ross, through his model, showed that reduction of mosquito numbers "below a certain figure" (Transmission threshold)...
Developing a malaria vaccine has been an arduous journey, complicated by the inherent complexity of the Plasmodium parasite's life cycle and its diverse antigenic characteristics [4]. Despite these challenges, there has been substantial progress. One particular advancement in this field is the RTS,S...
Models for malaria transmission are usually compared based on the quantities tracked, the form taken by each term in the equations, and the qualitative properties of the systems at equilibrium. Here five models are compared in detail in order to develop a set of performance measures that further...
This study assessed the protective effectiveness of monthly administration of SP + AQ (SPAQ) to children aged 3–59 months in Karamoja sub-region, Uganda, where parasite resistance is assumed to be high and malaria transmission is seasonal. Methods A two-arm quasi-experimental, open-label ...
Schematic diagram of the study design: A day before the commencement of the first cycle of SMC, 600 eligible children aged 1–14 years will be randomly assigned to one of three arms at a ratio of 1:1:1 to determine the safety, feasibility and tolerability of the SMC and anthelminthic ...
Eckhoff PA:A malaria transmission-directed model of mosquito life cycle and ecology. Malar J. 2011,, 10. [http://www.malariajournal.com/content/10/1/303], Google Scholar Download references Acknowledgements The authors would like to thank the National Institute for Mathematical and Biological Sy...
Fig. 1: Design of AnAPN1 transmission-blocking vaccine (TBV) constructs. Results Down-selection to the UF6 immunogen construct Establishing a large-scale cGMP production process for UF6b Fig. 2: Process flow diagram for UF6b manufacture. ...
The eradication of Plasmodium vivax malaria is complicated due to the presence of hypnozoites, the hidden dormant form of the parasite that is present in the liver. Currently available drug regimens are effective at killing hypnozoites but cause side eff