[3] Warfvinge K, Edvinsson L. Distribution of CGRP and CGRP receptor components in the rat brain [J]. Cephalalgia, 2019, 39, 342-353. [4] Dubowchik GM, Conway CM, Xin AW. Blocking the CGRP pathway for acute and preventive treatment of...
[6] YU SY,KIM BK,GUO AH,et al. Safety and efficacy of rimegepant orally disintegrating tablet for the acute treatment of migraine in China and South Korea:a phase 3, double-blind, randomised, placebo-controlled tria...
偏头痛(Migraine)是一种常见的慢性神经血管性疾病,其临床表现为反复发作的、单侧或双侧、具有搏动性的中度至重度头痛,世界卫生组织将其列为全球第三大最普遍疾病和第二大致残的神经系统疾病。 据统计,全球约有13亿偏头痛患者,美国约有4700万例,中国是全球偏头痛患病人数最多的国家,已经超过1.32亿。2020年,偏头痛...
[6]Yu S,Kim BK,Guo A,et al.Safety and efficacy of rimegepant orally disintegrating tablet for the acute treatment of migraine in China and South Korea:a phase 3,double-blind,randomised,placebo-controlled trial.Lancet Neurol.2023 Jun;22(6):476-484....
, Yonsei University in Seoul, South Korea, reviewed the role of calcitonin gene-related peptide (CGRP)鈥搕argeted therapies in migraine management, highlighting the efficacy and safety of the oral CGRP receptor antagonist (RA), rimegepant, in both acute treatment and prevention of migraine....
Calcitonin gene-related peptide (CGRP) has been shown to play causative role in induction of migraine attacks. Therefore, drugs blocking CGRP for migraine have been developed. Currently, three mAbs for CGRP or CGRP canonical receptor (Aimovig®, Ajovy® and Emgality®) have been approved ...
[2].Richard B. Lipton,et al. Effect of Ubrogepant vs Placebo on Pain andthe Most Bothersome Associated Symptom in the Acute Treatment of Migraine: TheACHIEVE II Randomized Clinical Trial.JAMA. 2019;322(19):1887-1898 [3].FDA、Allergan等官网...
原文出处:Biohaven's NURTEC ODT (rimegepant 75mg) is Now Available in U.S. Pharmacies for the Acute Treatment of Migraine in Adults 版权声明 本网站所有注明“来源:生物谷”或“来源:bioon”的文字、图片和音视频资料,版权均属于生物谷网站所有。非经授权,任何媒体、网站或个人不得转载,否则将追究法律责...
acute migraine model in rats was used to evaluate the anti-migraine effects of CRCR and the individual herbs using behavior, real time polymerase chain reaction and Western blot experiments. The absorption characteristics of active components involved in the anti-migraine action were analyzed by UPLC...
for the Acute Treatment of Migraine in China and South Korea. Retrieved February 14, 2022, from https://www.prnewswire.com/news-releases/biohaven-and-pfizer-announce-positive-topline-results-of-pivotal-trial-of-rimegepant-for-the-acute-treatment-of-migraine-in-china-and-south-korea-301481322....