[2]中国偏头痛防治指南,2016 [3]Themarket for migraine drugs [4]从曲坦类偏头痛用药看国内外市场差异 [5]CGRP and theTrigeminal System in Migraine 药事纵横是一个开放,由自愿者组成的团体,由以下成员组成:Voyager88,雷道安,Herman,梅希,文竹,du...
CGRP and the Trigeminal System in Migraine 2019, Headache CGRP as the target of new migraine therapies - Successful translation from bench to clinic 2018, Nature Reviews Neurology The role of calcitonin gene-related peptide in peripheral and central pain mechanisms including migraine 2017, Pain Calcit...
Calcitonin gene-related peptide (CGRP), a neuropeptide abundant in the trigeminal system and widely expressed in both the peripheral and central nervous systems, has recently emerged as a promising target for migraine management. While known as a potent arterial vasodilator, the role of CGRP in ...
Calcitonin gene-related peptide (CGRP), a neuropeptide abundant in the trigeminal system and widely expressed in both the peripheral and central nervous systems, has recently emerged as a promising target for migraine management. While known as a potent arterial vasodilator, the role of CGRP in mig...
Although still debated, many researchers consider migraine to be a disorder in which CNS dysfunction plays a pivotal role while various parts of the trigeminal system are necessary for the expression of associated symptoms.doi:10.1007/164_2018_201Lars Edvinsson...
It is primarily expressed in sensory neurons, and has been implicated in the regulation of pain, inflammation, vasodila- tion, and migraine headaches1–3. CGRP-containing neurons are widely distributed throughout the central nervous system, with particularly high levels of expression in the ...
Migraine is generally thought to involve abnormal signaling in the trigeminovascular system, and about 50% of trigeminal neurons have CGRP immunoreactivity. Although the notion that CGRP has a central site of action in relation to migraine had gained ground over the past decade, the recent ...
Migraine-specific acute medications currently in use include serotonin 5-HT1B/1D receptor agonists: triptans. These medicines are limited by the lack of efficacy in a substantial proportion of patients [12] and tolerability issues resulting in more than 95% of patients on a prescription medicine ...
Background聽聽The aberrant release of the neurotransmitters, glutamate and calcitonin-gene related peptide (CGRP), from trigeminal neurons has been implica... Yan,Xiao,Judith,... - 《Molecular Pain》 被引量: 131发表: 2008年 Emerging treatment for chronic migraine and refractory chronic migraine. ...
migraine, most notably with the prevalence of CGRP in trigeminal ganglia and PACAP in sphenopalatine ganglia. In rodents, the two peptides share activities, including vasodilation, neurogenic inflammation, and nociception. Most strikingly, CGRP and PACAP cause similar migraine-like symptoms in rodents...