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The neurotoxic fragment of Aβ, peptide 25–35, decreased significantly the NMDA receptor-mediated calcium, and calmodulin-dependent NO synthesis that may then be responsible for disturbances of the NO and cGMP signaling pathway. We concluded that cGMP -dependent signal transduction in hippocampus and...
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The development of small molecule modulators of NO/cGMP signaling for use in the CNS has lagged far behind the use of such clinical agents in the periphery, despite the central role played by NO/cGMP in learning and memory, and the substantial evidence that this signaling pathway is perturbed...
The finding of the presence of this crosstalk between the cGMP/PKG and H2S pathway downstream to the M1/M3 receptor in the human urothelium further implies a key role for H2S in bladder physiopathology. Thus, the modulation of the H2S pathway can represent a feasible therapeutic target to ...
Finally, chemical synthesis of the cell-permeable prodrug analogs that can be hydrolyzed to 2′,3′-cAMP/cGMP in plant cells will be useful to provide further evidence for their biological function and to explore a broader role of these cNMPs in plant stress biology. STAR★Methods Key ...
4.2. Using the cGMP Pathway for Biomarker Development Cell death in IRD, and in other neurodegenerative diseases, is often thought to be governed by apoptosis, a form of cell death that would display a number of characteristic markers, such as cytochrome c leakage and activation of caspase-typ...
the retina was light-adapted to saturate rods so that photopic cone-only responses could be recorded. Due to the low numbers of cones, the photopic a-wave was diminished by ~93%, whereas the RGC spiking responses were comparable to high-light scotopic responses (as the rod pathway relies ...
Exploring exotic superconductivity and topological physics in transition metal dichalcogenides, this work presents a novel pathway.Piper betle L., a highly regarded medicinal plant, is extensively utilized in diverse therapeutic settings, owing to its ample bioactive compound source. This research delved ...
Cyclic guanosine monophosphate (cGMP) is another type of a second messenger found in cell signaling pathway. It is a hydrophilic molecule derived from GTP. cGMP synthesis is catalyzed by the enzyme called guanylyl cyclase in the cells. cGMP acts as a second messenger in cell communication mostly...