cGAS Polyclonal Antibody for WB, IHC, IF/ICC, ELISAHost / Isotype Rabbit / IgG Reactivity human, mouse Applications WB, IHC, IF/ICC, ELISA and More (1) Conjugate Unconjugated Publications 11Cat no : 29958-1-AP Synonyms m-cGAS, mcGAS, Mb21d1, m cGAS ...
Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala66 of mouse cGAS protein. BackgroundCyclic GMP-AMP synthase (cGAS, MB21D1) is an antiviral enzyme that produces the second messenger cyclic-GMP-AMP (cGAMP) ...
Extrinsic phagocyte (macrophages and DCs)-dependent STING signaling is crucial to dictating the immunogenicity of dying tumor cells in the TME to activate potent antitumor T cells [152]. Tumor cell escape macrophage-mediated phagocytosis via increasing the CD47 expression, which recognizes signal regulat...
cGAMP levels were normalised to harvested cell numbers. c) Representative images of 250 nM reversine- or DMSO-treated BT549 cGASKO cells stained with DAPI (DNA) and an anti-STING antibody. Scale bar equals 5 µm. d) Quantification of cells with peri-nuclear or non-peri-nuclear STING ...
IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 5% w/v BSA, 1X TBS, 0.1% Tween® 20 at 4°C with gentle shaking, overnight. Applications Key W: Western Blotting W-S: Simple Western™ IP: Immunoprecipitation Cross-Reactivity Key M: Mouse Trademarks ...
(a chemotherapeutic agent) and CD47 blocking agents, including antagonistic anti-CD47 monoclonal antibody (mAb) increases type 1 IFN production by activating cGAS/STING signaling in myeloid antigen-presenting cells (APCs)/MICs in different cancers [154,155,156]. Furthermore, combining cGAMP with the...
cGAS-STING signaling pathway poster (KO) validated PrecisionAb Antibodies cGAS-STING antibody range References Products Research Areas Cancer Cancer Research Posters AKT Cell Signaling Pathway cGAS-STING Signaling Pathway EGF R Signaling Pathway Insulin Receptor Signaling Pathway mTOR Signalin...
After washing with the phosphate-buffered saline (PBS) buffer containing 0.2% Tween 20 (PBS-T), the membrane was incubated a peroxidase-labelled anti-mouse monoclonal antibody (Cell Signaling, Beverly, MA, USA) for 1 h, and the chromogenic reaction was performed using an ECL chemiluminescence...
cGas(-/-) mice were more susceptible to lethal infection with herpes simplex virus 1 (HSV1) than wild-type mice. We also show that cGAMP is an adjuvant that boosts antigen-specific T cell activation and antibody production in mice. 展开 ...
an Antibody byCell Signaling Technology Reactivity: Mus musculus (House mouse) (5483)Phospho-TBK1/NAK (Ser172) (D52C2) XP ® Rabbit mAb an Antibody byCell Signaling Technology Reactivity: Mus musculus (House mouse) (sc-33641)IRF3 Antibody (SL-12) ...