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binds to host or pathogen cytoplasmic DNA, promotes the formation of the second messenger cGAMP (cyclic GMP-AMP), and triggers STING (stimulator of interferon genes) dependent downstream signaling. Here we briefly describe the latest progress of the cGAS-cGAMP-STING pathway and...
The role of cGAMP via the STING pathway in modulating germinal center responses and CD4 T cell differentiationdoi:10.3389/fimmu.2024.1340001T cell differentiationGERMINAL centersT helper cellsB cell differentiationANTIBODY formationGerminal center (GC) responses are essential for establ...
STING 通路(Pathway) Immunology/Inflammation--STING CAS号(CAS NO.) 2407516-83-8 分子式(Formula) C20H22N10Na2O13P2 分子量(Molecular Weight) 718.37 外观(Appearance) 粉末 纯度(Purity) ≥98% 溶解性(Solubility) 溶于DMSO 结构式(Structure)
相关实验验证数据请参见:Targeting the cGAS-STING Pathway Using a Homogenous, HTS Compatible Transcreener? cGAS Assay Transcreener cGAMP cGAS试剂盒优势: 操作简便,高通量,兼容96, 384和1536孔模式~ 出色的信号稳定性:24小时以上的信号依旧稳定性
关键词:天然免疫;cGAS;STING;信号转导中图分类号;R392 文献标志码:ATheStudyofcGAS-cGAMP-STING-mediatedTypeIInterferonsSignalingPathwayWuXiao-xia,LvSong-ya*(CollegeofLifeSciences,WuhanUniversity,HubeiWuhan430072)Abstract:Theinnateimmunesystemisthefirstlineforhostdefenseagainstinvadingpathogens.Inrecentyears,...
cGAS-cGAMP-STING信号通路是固有免疫系统重要组成部分,通过识别胞浆DNA诱导I型干扰素(interferons,IFNs)和其他细胞因子产生,介导抗微生物先天免疫,同时也在肿瘤进展及远处转移中发挥作用。深入了解cGAS-cGAMP-STING信号通路与炎症性疾病、自身免疫性疾病及肿瘤发生发展的关系,以及STING激动剂的研究现状等,将对临床相关疾病...
STING (stimulator of interferon ) to activate the production of type I interferons . The host resistance to DNA vims infection is mainly dependent on the cGAS -cGAMP -STING-mediated type I interferons signaling pathway . The study of cGAS -cGAMP-STING ...
tastasis. In-depth understanding of the relationship between the cGAS-cGAMP-STING signaling pathway and in- flammatory diseases, autoimmune diseases, and tumor developmen, as well as the current research status of STING agonists, will provide theoretical support for the treatment of clinically related...