In the tissue array analysis, CFTR protein level decreased significantly in breast cancer and low CFTR protein level correlated with poor survival with a p﹙alue of 0.034. Thus, promoter hypermethylation of the CFTR gene might be a novel diagnostic marker of breast cancer. This article is ...
The breast cancer resistance protein (BCRP), formally known as ATP-binding cassette protein G2 (ABCG2), is an efflux transporter that plays a significant r... K Natarajan,MR Baer,DD Ross - Springer International Publishing 被引量: 243发表: 2015年 Molecular pharmacology of the CFTR Cl- chan...
Mutation and haplotype analysis of the CFTR gene in atypically mild cystic fibrosis patients from Northern Ireland Germline mutations in either of the two major breast cancer predisposition genes, BRCA1 and BRCA2, account for a significant proportion of hereditary breas... D Hughes,T Dörk,M St...
(CRPC). Now we show that EZH2 inhibitors can also block the transactivation task of EZH2 and prevent the growth of CRPC cells. Gene appearance and epigenomics profiling of cells addressed with EZH2 inhibitors demonstrated that as well as derepressing gene appearance, these compounds additionally ...
What is the human cytogenetic location of the CFTR gene? 7q31.2 What is the predicted molecular weight of CFTR? 168 kDa Where is CFTR expressed? CFTR is mainly expressed in apical membranes of vertebrate epithelial cells. What is the ion selectivity of CFTR? CFTR is an anion-selective channe...
The MT three gene can also be silent in cell lines derived through the UROtsa parent which have been malignantly transformed by both Cd 2 or As 3. A pattern of MT 3 mRNA expres sion just like that to the parental UROtsa cells was located following remedy with the Cd 2 and As three...
The potential impact of these modulator drugs on the treatment and prevention of GI cancers can provide a new example of personalized cancer medicine. Keywords: cystic fibrosis; CFTR; gastrointestinal cancers; tumor suppressor gene; modulators 1. Introduction Cystic Fibrosis is a monogenic disease ...
16.In Silico Cloning of Chloride Channel Gene(clc)from Zea mays and Bioinformatic Analysis一个玉米氯离子通道基因(clc)的电子克隆及生物信息学分析 17.Discovery of G551D-CFTR Mutant Chloride Channel Activators and GlpF E.coli Glycerol Channel Inhibitors by High-throughput Screening;CFTR Cl~-通道和Glp...
Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis. Interestingly, AEG-1 expression is elevated in subsets of breast cancer, glioblastoma multiforme and melanoma cells and AEG-1 cooperates with Ha-ras to ... Emdad,L. - ...
The authors report on a fluorometric method for the rapid detection of BRCA1, CFRT and MRP3 gene mutations. These are associated with breast cancer, cystic fibrosis and autoimmune hepatitis diseases, respectively. Carbon nanodots with blue fluorescence (with excitation/emission maxima at 340/440nm)...