Genetic effects on gene expression across human tissues. Nature 550, 204–213 (2017). One of several papers describing the results obtained from the Genotype-Tissue Expression (GTEx) project, which used RNA-sequence data from more than 40 human tissues in several hundred individuals to explore ...
Ye L, Chan S, Chow YH, Tsui LC, Hu J: Regulated expression of the human CFTR gene in epithelial cells. Mol Ther 2001, 3(5 Pt 1):723-733.Ye L,Chan S,Chow Y H,et al.Regulated expression of the human CFTR gene in epithelial cells. Molecular Therapy . 2001...
One problem with this approach is that, until recently, very few large genomic sequences were well annotated and only the coordinates of the coding exons within a gene could be considered. More- over, because methods did not exist to predict alternative splicing, the test sets used to ...
The MDR3 gene contains 28 exons and 27 of these contain coding sequences for the two homologous halves of the protein that correlate with functional domains. This structure is virtually identical to that of the human MDR1 gene and the mouse mdr1 (mdr1b) gene, indicating that the exon/...
For years scientists referred to noncoding DNA as “junk DNA.” But it’s become clear that some noncoding sequences regulate gene expression and protein formation. “We want to characterize the whole genomic landscape and integrate WGS into the human multi-omic framework built by the Population...
For single-cell RNA sequencing, besides the organs for transplantation purposes, we collected tissues from 15 organs in sequence, including the blood, bone marrow, liver, common bile duct, lymph node (hilar and mesenteric), spleen, heart (apical), urinary bladder, trachea, esophagus, stomach, ...
A subsequent GWAS meta-analysis conducted by the same group has found a locus of susceptibility to CWP in a non-conding region between the chaperonin-containing T-complex polypeptide 1 (TCP1)-complex-5 gene, CCT5, and FAMily with sequence similarity 183 member B gene, FAM183B (Peters et ...
蛋白别名: ATP-binding cassette protein C11; ATP-binding cassette sub-family C member 11; ATP-binding cassette transporter MRP8; ATP-binding cassette transporter sub-family C member 11; ATP-binding cassette, sub-family C (CFTR/MRP), member 11; multi-resistance protein 8; Multidrug resis...
4.A signature of balancing selection in the region upstream to the human UGT2B4 gene and implications for breast cancer risk 机译:UGT2B4基因上游区域平衡选择的标志及其对乳腺癌风险的影响 作者:Chang Sun;Dezheng Huo;Catherine Southard;Barbara Nemesure;Anselm Hennis;M. Cristina Leske;Suh-Yuh Wu;...
not available for EP1242619of corresponding document: WO0121833 A diagnostic method for the detection of the 5T, 7T and 9T alleles in intron (8) of the human CFTR gene which method comprises contacting a test sample of nucleic acid from an individual with a multiplex of diagnostic primers ...