Autoimmune cerebellar ataxias (ACA) encompass a heterogeneous group of disorders characterized by isolated or predominant cerebellar dysfunction caused by immune-mediated mechanisms. ACA include well-characterized entities with a clear trigger and/or association with specific neuronal antibodies, such as para...
Among the different forms of cerebellar ataxia, autoimmune cerebellar ataxia (ACA) or immune鈥恗ediated cerebellar ataxia (IMCA), which appears to be based on an autoimmune mechanism, has long been considered important from the viewpoint of paraneoplastic syndrome. With the expansion of the concept...
However, a few cases of low-titer GAD antibody-positive cerebellar ataxia patients have been described recently. In such patients, the antibody has been detected predominantly in serum, rather than in cerebrospinal fluid. Case presentation: A 34-year-old man presented with subacute-onset cerebellar...
Spinocerebellar ataxia7 designates the locus onchromosome 3, the gene name and the disease associatingcerebellar ataxiawithmacular degeneration. SPT3/TAF9/GCN5acetyltransferasecomplex involved intranscription regulation. TFTC Tata binding protein-free TAF-containing complex involved in transcription regulation....
ataxias is no different to the one found in the healthy population [9]. The HLA DQ2 has been shown to have a strong association with autoimmune diseases, such as celiac disease and gluten ataxia, type 1 diabetes mellitus, stiff person syndrome, autoimmune thyroid disease and autoimmune poly...
摘要: Cerebellar ataxia is one of the most frequent syndromes associated with autoantibodies against glutamic acid decarboxylase (GAD-ab). Antibodies recognize the isoform GAD65, which is the standard biomarker, but additional immunoreactivity against GAD67...
Conclusion Some patients with cerebellar ataxia have autoimmune conditions and diagnosing autoimmune cerebellar ataxia is therefore an important component in the care of patients with this disease entity. 展开 关键词: cerebellar ataxia anti-GAD antibody gluten ataxia anti-thyroid antibody immunotherapy ...
autoimmune cerebellar ataxia AChR: acetylcholine receptor ADEM: acute disseminated encephalomyelitis AF: Alexa Fluor® AGNA: anti-glial cell nuclear antibodies AMPA: α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ANA: anti-nuclear antibodies ...
None of the patients had significant past medical history of autoimmune diseases or a family history of cerebellar ataxia. Paraneoplastic antibodies and malignancy workup were negative. Brain MRIs were normal in Patient 1 and 2. Patient 3's MRI revealed cerebellar atrophy and abnormal signal ...
paraneoplastic cerebellar degenerationprimary autoimmune cerebellar ataxiaWe note Dr Wills' and Dr Unsworth's continued scepticism at the concept of gluten ... M Hadjivassiliou - 《Cns & Neurological Disorders Drug Targets》 被引量: 3发表: 2017年 IFN-γ is a therapeutic target in paraneoplastic cer...