2662Poster Board II-638The differentiation of central memory CD8+ T cells after vaccination or primary pathogen encounter is critical for the establishment of long-lasting protection against pathogens including intracellular infectious organisms and malignancies. Unfortunately, the mechanisms of immune memory...
The mechanisms underlying the heightened protection mediated by central memory CD8+ T (TCM) cells remain unclear. Here we show that the transcription factor Tcf1 was required in resting TCM cells to generate secondary effector CD8+ T cells and to clear p
however, tumor recurrence remains a concern. Central memory CD8+T cells (TCM) play important roles in protection from chronic infection and cancer. Here we find, by single-cell RNA analysis of human breast cancer samples, that although the memory phenotype...
Central memory CD8+ T cells (Tcm) control systemic secondary infections and can protect from chronic infection and cancer as a result of their stem-cell-like capacity to expand, differentiate, and self-renew. Central memory is generally thought to emerge following pathogen clearance and to form ...
Altered proportions of naive, central memory and terminally differentiated central memory subsets among CD4+ and CD8 + T cells expressing CD26 in patients with type 1 diabetes. J Clin Immunol. 2011; 31 :977–84.Matteucci E, Ghimenti M, Di Beo S, Giampietro O (2011) Altered proportions of...
These re-directed T cells specifically lysed NY-ESO-1157–165/HLA-A*02:01-positive cells and secreted IFNγ. A total of 40% of CCR7− re-directed T cells had an effector memory phenotype and 5% a central memory phenotype. Based on CCR7 cell sorting, effector and memory CAR-positive T...
Induction of a central memory and stem cell memory phenotype in functionally active CD4(+) and CD8(+) CAR T cells produced in an automated good manufacturing practice system for the treatment of CD19(+) acute lymphoblastic leukemia. Cancer Immunol Immunother. (2018) 67:1053-66. doi: 10.1007...
文档标签: The Double Benefit of ex-vivo Generated Anti 3rd Party CD8 系统标签: gvhd engraftment gvl vivo phenotype cells patients,donorhematopoiesisisaccountedforbyoneunit,althoughthemechanismsofunitdominancearenotestablished.CordbloodNKcellsarepredominantlyofamaturephenotype,withcytotoxicactivityfollowingIL-2st...
Cell frequencies among all CD8β+ T cells are shown for both the naive and memory gate. (C) CCR7 expression, as determined by staining with CCL19-Ig chimera, on naive (solid line) and memory (dotted line) CD8β+ T cells in BM. A histogram for peripheral blood memory CD8+ T cells ...
Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naive cells Nat Immunol (2001) R.L. Reinhardt et al. Visualizing the generation of memory CD4 T cells in the whole body Nature (2001) C. Zaph et al. Central memory T cells mediate long-term ...