Central memory CD8+ T cells (Tcm) control systemic secondary infections and can protect from chronic infection and cancer as a result of their stem-cell-like capacity to expand, differentiate, and self-renew. Central memory is generally thought to emerge following pathogen clearance and to form ...
Human effector T cells derived from central memory cells rather than CD8T cells modified by tumor-specific TCR gene transfer possess superior traits for adoptive immunotherapy. Cancer Lett 2013; 339(2):195-207.F. Wu, W. Zhang, H. Shao, H. Bo, H. Shen, J. Li, Y. ...
Whereas effector memory (EM) T cells (CD62LloCCR7neg) quickly express effector functions upon restimulation and preferentially migrate to tissues and spleen, central memory (CM) T cells (CD62LhiCCR7pos) have hybrid properties of both nave (N) and effector cells. Like N cells, their adhesion...
机译:体外产生CD8〜+ T中央记忆细胞 获取原文 获取原文并翻译|示例 获取外文期刊封面目录资料 开具论文收录证明 >> 文献代查 >> 文献数据库(团队版) >> 摘要 Naive CD8~+ T cells differentiate into effector CTL after Ag encounter.Although induction and persistence of central memory cells are critical ...
The mechanisms underlying the heightened protection mediated by central memory CD8+ T (TCM) cells remain unclear. Here we show that the transcription factor Tcf1 was required in resting TCM cells to generate secondary effector CD8+ T cells and to clear p
In unimmunized specific pathogen-free mice, there are unique memory-type CD8(+) T cell populations expressing asialoGM1 (ASGM1). These cells were classified into central memory-type T cells (T(CMT)) judging from their expression profile of CD44, IL-2Rbeta, CD62L and CCR7 cell-surface mo...
Treating T cells harvested from a patient with a combination of an epigenetic drug and a cytokine while expanding the cells in the lab re-programs them into a stronger T cell type that persists longer than its comrades, researchers ...
EC displayed significantly greater activation levels than VS, with a higher contribution of central memory subsets to the activation of total CD8 T cells (p = 0.002). The activation of central memory CD8(+) T cells significantly correlated with viral load in TP regardless of CD4 counts. In ...
Additionally, CNI treatment inhibited all stages of T cell exhaustion, promoting memory T cell expansion with high clonality, particularly within the CD4+ compartment. PT-Cy, on the other hand, effectively deleted alloreactive T cells, reduced IL-17A–producing cells,...
Cell frequencies among all CD8β+ T cells are shown for both the naive and memory gate. (C) CCR7 expression, as determined by staining with CCL19-Ig chimera, on naive (solid line) and memory (dotted line) CD8β+ T cells in BM. A histogram for peripheral blood memory CD8+ T cells ...