CellularResponsetoHypoxia Thecellularresponsetohypoxiahasbecomeofmedicalinterest,ashypoxiacausesbroadphysiological changesinthecell.Originallyidentifiedasaregulatoroferythropoietin(EPO)andvascularendothelial growthfactor(VEGF),hypoxia-induciblefactor-1alpha(HIF-1alpha)isamajorglobalregulatorofthe hypoxicresponse(Semenza...
The purpose of this article is to highlight the cell's response to hypoxia at the level of the gene. The review specifically does not deal with genetic changes as a consequence of reperfusion, which are different pathways from the genetic changes induced by acute hypoxia. This article is not...
His work became the supporting foundation for a succession of discoveries in the area of respiratory physiology by great investigators, such as Paul Bert (1833–1886), who hypothesized that an organ response to hypoxia was the result of decreases in intracellular PO 2 . In recent times we have...
内容提示: Cellular Response to Hypoxia The cellular response to hypoxia has become of medical interest, as hypoxia causes broad physiological changes in the cell. Originally identified as a regulator of erythropoietin (EPO) and vascular endothelial growth factor (VEGF), hypoxia-inducible factor-1 ...
Cellular Response to Renal Hypoxia Is Different in Adolescent and Infant Rats SHINSUKE ADACHI, SERGEY ZELENIN, YASUTAKA MATSUO, AND ULLA HOLTBÄCK Department of Woman and Child Health, Karolinska Institutet, S-171 76 Stockholm, Sweden [S.A., S.Z., Y.M., U.H.]; and Department of ...
Hypoxia is commonly found in human solid cancers and serves as a selective environment for the survival of aggressive cancer cells and as protection from anti-cancer therapies. In addition to a shift to anaerobic metabolism, the cellular response to hypoxia includes cessation of cell division and/...
Reviews15 April 2003Malignant Glioma Physiology: Cellular Response to Hypoxia and Its Role in Tumor ProgressionDaniel J. Brat, MD, PhD and Timothy B. Mapstone, MDDaniel J. Brat, MD, PhDFrom Emory University School of Medicine, Atlanta, Georgia.Search for more papers by this author and Timoth...
Relative hypoxia has been shown to develop in white adipose tissue depots of different types of obese mouse (genetic, dietary), and this leads to substantial changes in white adipocyte function. These changes include increased production of inflammation-related adipokines (such as IL-6, leptin, Ang...
The tumour suppressor activity of p53 in vivo can be subject to pressure from the physiological stress of hypoxia and we report on the development of a cell system to define the p53-dependent stages in the adaptation of cells to hypoxia. p53+/+ cells exp
Ventilatory response to hypoxia : integrated, cellular, and molecular aspects In this work we studied antioxidant status and cellular immunity of ark shells ( A. broughtonii ) to determine the range of the adaptive potential to hypox... G Haddad,C Rosen - 《Lung Biology in Health & Disease》...