CellularResponsetoHypoxia Thecellularresponsetohypoxiahasbecomeofmedicalinterest,ashypoxiacausesbroadphysiological changesinthecell.Originallyidentifiedasaregulatoroferythropoietin(EPO)andvascularendothelial growthfactor(VEGF),hypoxia-induciblefactor-1alpha(HIF-1alpha)isamajorglobalregulatorofthe hypoxicresponse(Semenza...
His work became the supporting foundation for a succession of discoveries in the area of respiratory physiology by great investigators, such as Paul Bert (1833–1886), who hypothesized that an organ response to hypoxia was the result of decreases in intracellular PO 2 . In recent times we have...
内容提示: Cellular Response to Hypoxia The cellular response to hypoxia has become of medical interest, as hypoxia causes broad physiological changes in the cell. Originally identified as a regulator of erythropoietin (EPO) and vascular endothelial growth factor (VEGF), hypoxia-inducible factor-1 ...
Cellular Response to Renal Hypoxia Is Different in Adolescent and Infant Rats SHINSUKE ADACHI, SERGEY ZELENIN, YASUTAKA MATSUO, AND ULLA HOLTBÄCK Department of Woman and Child Health, Karolinska Institutet, S-171 76 Stockholm, Sweden [S.A., S.Z., Y.M., U.H.]; and Department of ...
functional characteristics in the pathway of phagocytosis leading to oxidative burst, hypoxia, cellular response to hypoxia and finally the pro-inflammatory ... M Emam,S Tabatabaei,M Sargolzaei,... - 《Frontiers in Immunology》 被引量: 0发表: 2021年 Cellular response to tissue hypoxia and its...
Relative hypoxia has been shown to develop in white adipose tissue depots of different types of obese mouse (genetic, dietary), and this leads to substantial changes in white adipocyte function. These changes include increased production of inflammation-related adipokines (such as IL-6, leptin, Ang...
Firstly, acute hypoxia rapidly activates the endothelial cells to release inflammatory mediators and growth factors. These inflammatory mediators are able to recruit and promote the adherence of neutrophils to the endothelium where they become activated. The synthesis of platelet-activating factor plays a...
The cell response to hypoxia has a complex diversity. Hypoxia-inducible factor( HIF) pathway in an oxygen dependent manner plays a central role during the hypoxia response. The HIF-independent pathways are equally important under hypoxic conditions which can maintain the oxygen balance and metabolism...
Other biological molecules have also been reported to be involved in the radioresistance in tumor cells under hypoxic conditions (8). A major cellular response to hypoxia is the activation of hypoxia induced factor 1 (HIF-1)1 a transcription factor, which has been implicated in the regulation ...
The tumour suppressor activity of p53can be subject to pressure from the physiological stress of hypoxia and we report on the development of a cell system to define the p53-dependent stages in the adaptation of cells to hypoxia. p53cells exposed to hypoxia exhibited a transient arrest in G2/...