Overexpression of MLF1IP promotes colorectal cancer cell proliferation through BRCA1/AKT/p27 signaling pathway Yuting Xu, Lin Zhang, Qingling Wang, Maojin Zheng Article 110273 select article Nicorandil alleviates cardiac remodeling and dysfunction post -infarction by up-regulating the nucleolin/autophagy ...
be characterized by the activation of the DNA damage response (DDR) signaling pathway. Well-known triggers of cellular senescence are also activated oncogenes (ie, Ras, BRAF, E2F3) and inactivated tumor suppressor (ie, RB, PTEN, NF1, and VHL), but there are other less investigated inducers...
Mechanisms of Interorgan Communication and Impact on Pathophysiology Edited byMichael Tranter,Kristin Stanford 3 July 2023 Underlying molecular pathways in urological cancer progression and therapy resistance Edited byGautam Sethi,Milad Ashrafizadeh,Yuzhuo Wang,Francesco Crea,Navid Rabiee ...
Disulfiram inhibits LPS-induced TLR4/NF-κB signaling in spheroids derived from human colorectal cancer cells Narayanan Poornima Devi Warrier Vidya Devarajan Karunagaran Original Article18 October 2024 Benzo(a)pyrene-loaded gypsum dust-induced apoptosis of human bronchial epithelial cells through the Ahr ...
including immune responses and cell signaling [3]. The key factor lies in maintaining a delicate balance between the production of ROS and the antioxidant defense systems within cells [4]. Understanding the role of oxidative stress in cancer pathogenesis has spurred research efforts to develop antiox...
I. Cell-intrinsic transforming growth factor-β signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo. Immunity 31, 145–157 (2009). CAS PubMed PubMed Central Google Scholar Garidou, L., Heydari, S., Gossa, S. & McGavern, D. B. Therapeutic blockade of ...
signaling mediators (IL-6R and Stat-3) and expression of genes implicated in costimulation (Ox40, CD40L and ICOS), potentially compromising high-affinity B-cell maturation and development of long-lived memory B cells [80,81,82]. While the specific impact of HIV infection on the SARS-CoV-2...
Cellular and Molecular Neurobiology is a peer-reviewed journal focused on the analysis of neuronal and brain function at cellular and subcellular levels. Editor Juan M. Saavedra Journal Impact Factor 3.6 (2023) 5-year Journal Impact Factor
In addition, Klotho forms a complex with fibroblast growth factor 23 receptor, the subsequent signaling of which is involved in the regulation of vascular calcification and osteoporosis [94]. 4.2.3. Sirtuins Sirtuins (SIRT1−7) constitute an evolutionarily conserved family of NAD1-dependent ...
Future improvements can involve the integration of complex signaling pathways, immune responses, hypoxia, nutrient transport, and mechanical stresses, such as oncotic pressure or laminar flows affecting the tumor surface. In conclusion, the HCA model represents a promising tool for investigating the ...