Cellular senescence and organismal ageing in the absence of p21(CIP1/WAF1) in ku80(−/−) mice. EMBO Rep. 2009;10(1):71–8. CentralZhao B, Benson EK, Qiao R, Wang X, Kim S, Manfredi JJ, Lee SW, Aaronson SA (2009) Cellular senescence and organismal ageing in the absence of...
近日,北京大学邱义福团队在Immunity 在线发表题为“Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging”的研究论文,该研究发现2型细胞因子信号缺乏能够加速衰老,相反,白细胞介素-4 (IL-4)-STAT6途径保护巨噬细胞免于衰老。#北京大学#衰老细胞#白细胞#免疫 ...
Cellular senescence and organismal ageing in the absence of p21CIP1/WAF1 in ku80–/– mice. EMBO Rep 2009; 10: 71–8. 35 Kuroda Y, Aishima S, Taketomi A, Nishihara Y, Iguchi T, Taguchi K, et al. 14-3-3sigma negatively regulates the cell cycle, and its down-regulation is ...
Conversely, STAT6 deficiency induced release of nuclear DNA into the cytoplasm to promote tissue inflammation and organismal aging. Importantly, we demonstrate that IL-4 treatment prevented macrophage senescence and improved the health span of aged mice to an extent comparable to senolytic treatment, ...
Although p53 is a well-known potent tumor suppressor, its role during cellular senescence and organismal aging in normal human cells, particularly that of epithelial origins, remains controversial. The current study was undertaken to examine the expression pattern of p53 in normal human oral ...
M. Cellular senescence and organismal aging. Mech. Ageing Dev. 129, 467–474 (2008). Article PubMed PubMed Central CAS Google Scholar Coppe, J. P., Desprez, P. Y., Krtolica, A. & Campisi, J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu. ...
de magalhaes jp, passos jf. stress, cell senescence and organismal ageing. mech ageing dev. 2018;170:2–9. article cas pubmed google scholar storer m, mas a, robert-moreno a, pecoraro m, ortells mc, di giacomo v, et al. senescence is a developmental mechanism that...
funded, many aspects of this complexity are often overlooked. In this review, we will discuss one such interaction, between cellular senescence and the immune system with a focus on the accumulation of SnCs in the lymphoid organs of the aging body, which is greatly understudied and ...
Senescent cell extrinsic activities, broadly related to the activation of a senescence-associated secretory phenotype, amplify the impact of cell-intrinsic proliferative arrest and contribute to impaired tissue regeneration, chronic age-associated diseases and organismal ageing. This Review discusses the ...
Afanasev (Oxid Med Cell Longev. 2010 March-April; 3(2):77-85) reports reactive oxygen species (ROS) superoxide and hydrogen peroxide perform important signaling functions in many physiological and pathophysiological processes. Cell senescence and organismal age are not exemptions. Aging-regulating gene...