5.Study on the Reactivity of Chronic Myeloid Leukemia Cells and the Responsive Genes to IFN-alpha;CML细胞对干扰素-α的反应性及其应答基因的研究 6.Peptide-specific Allogeneic T-cell Response Induced and Modulated by Peptide/HLA-A2 Complex in Vitro;抗原肽/HLA-A2复合物诱导和调节同种反应性T细胞的应...
T-cell responses to peptide fragments of the BK virus T antigen: implications for cross-reactivity of immune response to JC virus. Infection with BK virus (BKV) induces both humoral and cellular immunity, but the viral antigens of T-antigen (T-ag) stimulating T-cell responses are large......
The putative role of GRP78 in coupling rates of translation to processing is modeled, and functional relationships between the HSP and GRP chaperone systems are discussed. 展开 关键词: Peptide Chain Initiation Stress eIF-2 Heat-Shock Proteins 肽链起始 应激 ...
Targeting cyclin-dependent kinases in human cancers: from small molecules to peptide inhibitors. Cancers 7, 179–237 (2015). Article CAS PubMed Google Scholar Weinberg, R. The Biology of Cancer (Garland science, 2013). Li, Y. et al. A novel histone deacetylase pathway regulates mitosis by...
and GM-CSF and antimicrobial peptide LL37 complexed with mammalian DNA (LL37/DNA, TLR-9 ligand)21. Transcriptional profiles were generated using Affymetrix microarrays in the conditions 0, X, Y and X+Y, at one or two time points for each pair of signals, in order to get a multiparametric...
Dynamic exclusion for 20 s was enabled to prevent the repeated sequencing of peptides. 2.3. MS Bioinformatics and Data Analyses MS bioinformatics and data pre-processing were performed as described previously [45]. Principle component analysis (PCA) was performed in the Perseus environment by median...
Recently, a peptide that was encoded by telomerase RNA (TERC) was shown to play a role in the protection of drug-induced apoptosis and autophagosome formation [22]. However, since both WT and nuchTERT-expressing cells express TERC, it is unlikely that this peptide plays a differential role ...
(TCR), a membraneheterodimerthat is associated with theCD3signaling complex. TheTCRbinds peptides, processed from pathogens and malignant cells, which are bound to proteins encoded by genes in themajor histocompatibility complex(MHC). Other components of the cellular immune response, such asNK cells...
(A) Crystal structure of the coumestrol (COU)-bound LBD dimer in an active conformation where helix-12 (h12) docks across h11 and h3, with an SRC2 peptide docked at the AF2 surface. The ligand is shown as spheres. (B) The zearalenone (ZEN)/ERα-LBD structure (coral) was superposed...
Monocyte chemotactic peptide (MCP-1), which is secreted by HSCs, can stimulate KC infiltration [100, 102]. These recruited KCs or other immune cells not only have regulatory effects on liver regeneration but also provide additional signals, such as IL-13, to enhance the fibroblast activity of...