Lipogenesis, the process of fatty acid and subsequent triglyceride synthesis, occurs primarily in the liver and adipose tissue [11,12]. This process is highly sensitive to dietary changes. A carbohydrate-rich d
OVGP1 is a hormonally-regulated, carbohydrate-rich and traditionally-expressed protein-coding gene known to regulate receptivity and trophoblast adhesion. Alimiñana et al. [26], investigated the differential pro- tein contents in BOECs and oviduct-derived EVs from in vivo and in vitro...
Ketone bodies also modulate the NLRP3 inflammasome. β-Hydroxybutyrate (BHB) is a ketone produced in the liver that can be used as an energy source in animals on a low-carbohydrate diet (the so-called ketogenic diet) or under conditions of nutrient deprivation. BHB efficiently blocks the NLRP...
Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) pathway enrichment analysis were performed using the “clusterProfiler” R package; a Benjamini–Hochberg correctedP-value < 0.05 was considered significant [24]. For GO pathway enrichment, only “Biological Process” GO term...
To protect the interior of the cell from these degradative enzymes, the integrity of the limiting membrane has to be preserved during the process of lysosomal degradation. This is achieved by a thick glycocalyx [22] composed of the carbohydrate part of lysosomal integral membrane proteins (LIMPS)...
Under high-energy demand or metabolic stress conditions, ACSS2 plays a crucial role by utilizing non-carbohydrate substrates like acetate to maintain cellular energy homeostasis [17]. Our subsequent investigation of ACSS2 levels in brain tissue demonstrated a substantial decrease in both cortical and ...
and pyroptosis [42,43]. Among them, autophagy as a high conserved cellular process is thought to be critical in affecting cell survival. Hepatocytes are dependent on basal autophagy to supple energy because of the high biosynthetic activity and carbohydrate storage. Furthermore, the activation of ...
(Fig.1a). Although presented in a sequential manner, it is important to perceive it as a simultaneous, interdependent process. The starch-biosynthetic enzymes are well conserved between different plant species, suggesting a common origin [33]. The basic mechanism of starch biosynthesis resembles ...
The GPEA of the S. cerevisiae GRN-TRN interface comprises 39 terms with pfdr≤0.01 (Figure4B). The processes involve the positive regulation of metabolic and biosynthetic processes (RNA), regulation of gene expression, galactose and alcohol metabolic process and response to chemical stimulus. The...
J. Carbohydrate bis-acetal-based substrates as tunable fluorescence-quenched probes for monitoring exo-glycosidase activity. J. Am. Chem. Soc. 139, 8392–8395 (2017). Article CAS PubMed Google Scholar Lee, J.-H. et al. PET quantification of brain O-GlcNAcase with [18F]LSN3316612 in ...