In this Review, Jan van Deursen and his colleagues discuss the recent progress in understanding the origin and identity of senescent cells in ageing and their contribution to age-related disease, in addition to discussing the potential for targeting thes
Lorenzini A, Maier AB (2016) Influence of donor age and species longevity on replicative cellular senescence. In: Rattan SIS, Hayflick L (eds) Cellular ageing and replica- tive senescence, 1st edn. Springer International Publishing, New York, pp 49-70Lorenzini, A. & Maier, A.B., 2016. ...
Mild cognitive impairment (MCI), AD, brain atrophy, and brain hypo-perfusion are all more likely to occur with aging (Albert et al., 2011). Given that ageing is a major risk factor for many neurodegenerative and other diseases, there is growing interest in targeting fundamental aging mechanism...
Apoptosis is a genetically programmed cell death and p53 is very important in the regulation of senescence. The senescent CD8 T-cells have effects on both immune on non-immune systems. The deterioration of T-cell functions with ageing is called as immunosenecence. Telomere shortening is the ...
and underlying mechanisms in which replication stress is driving not only cellular senescence but also the accelerated decline of bodily function, including (but not exclusively) replicative tissues characterized by persistent inflammatory processes. Some salient and notable points are discussed in this ...
The various signaling networks responsible for the anti-ageing and anti-senescence activity of SIRT1 have been discussed. In particular, a counter-balancing model involving the cross talks between SIRT1 and AMP-activated protein kinase (AMPK), another stress and energy sensor, is suggested for ...
Kurz DJ, Decary S, Hong Y, Erusalimsky JD (2000) Senescence-associated β-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells. J Cell Sci 113:3613–3622 PubMedCAS Chang B-D, Broude EV, Dokmanovic M, Zhu H, Ruth A, Xuan Y, Kandel...
Hence, this review mainly discusses the relationship between the two phenomena to show the striking similarities between SASP and CKD-associated secretory phenotype (CASP). It has been reported that replicative senescence, stress-induced premature ageing, and epigenetic abnormalities participate in the ...
Cellular senescence and organismal ageing in the absence of p21CIP1/WAF1 in ku80–/– mice. EMBO Rep 2009; 10: 71–8. 35 Kuroda Y, Aishima S, Taketomi A, Nishihara Y, Iguchi T, Taguchi K, et al. 14-3-3sigma negatively regulates the cell cycle, and its down-regulation is ...
Cellular senescence, ageing and disease Cellular senescence is the irreversible growth arrest of individual mitotic cells, which as a consequence display a radically altered phenotype that is tho... DGA Burton - AGE 被引量: 204发表: 2009年 Oocyte ageing and its cellular basis Aneuploidy is extreme...