EVs are small membrane-enclosed particles that are secreted to mediate the transfer of DNA, RNA, proteins and lipids between cells [15]. Recent studies have highlighted a crucial role for a major subset of EVs called small EVs (sEVs; 30–200 nm in diameter) in GBM through their ability ...
et al. Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis. J. Hepatol. 57, 141–149 (2012). CAS PubMed Google Scholar Kudo, H. et al. Lipopolysaccharide triggered TNF-alpha-induced hepatocyte apoptosis in a murine non-...
Grosjean K, Mongrand S, Beney L, Simon-Plas F, Gerbeau-Pissot P (2015) Differential effect of plant lipids on membrane organization: specificities of phytosphingolipids and phytosterols. JBC 290(9):5810–5825. https://doi.org/10.1074/jbc.M114.598805 Article CAS Google Scholar Gruber S, ...
The induction of cellular adhesion molecules, such as VCAM-1, ICAM-1, and selectins, to the endothelial surface appears, then, to be an early event in atherogenesis. These molecules are not constitutively expressed on the surface of the normal endothelium, and their expression appears to be re...
The synthesis of lipids is a key component in membrane remodeling. In M1 macrophages the process depends on the production of acetyl-CoA from citrate ATP-citrate lyase [86]. The activity of this enzyme rapidly increases in activated macrophages. Intracellular fatty acids can also be used to synt...
Are secretory vesicles and cellular adhesion molecules within the intracellular fluid, extracellular fluid or both?Secretory Vesicles:Through a process known as exocytosis, secretory vesicles help move chemicals outside of the cell. They are necessary for the pr...
3、embrane4Chemical composition and molecular structure of cell membraneAll plasma membranes consist mostly of lipids (fats) and proteins plus small amounts of carbohydrate.Lipid bilayer Electron micrograph Fluid mosaic model The most abundant membrane lipids are phospholipid. Speciality FunctionsCell 4...
ROS are hallmarks of oxidative damage. The effects of an imbalanced redox status of cells primarily involve the modification of redox-sensitive molecules, such as the oxidation of cysteine and methionine in proteins, the peroxidation of lipids, and the oxidation of DNA bases [13]. The ...
Valvular inflammation triggered by hyperlipidemia has been considered as an important initial process of aortic valve disease; however, cellular and molecular evidence remains unclear. Here, we assess the relationship between plasma lipids and valvular i
Cardiovascular disease (CVD) is the leading cause of mortality worldwide [104]. The underlying pathological process of CVD is atherosclerosis, a slowly progressing chronic disorder of large and medium-sized arteries that is characterized by the accumulation of lipids in the arterial wall, the infiltr...