Among the lymphoid tissues, the thymus has NK cells with surface marker phenotypes resembling immature cNK cells [2]. Specifically, as compared to splenic cNK cells that are Ly49hi CD11bhi, thymic NK cells are Ly49low CD11blow, like immature BM cNK cells. However, thymic NK cells are CD...
development, and morphogenesis, which are developmental processes featuring programmed senescence events [28,29]. Senescent cells are detectable in various tissues and organs, especially in the kidney [30], inner ear [31], limbs,
The heterogeneity of MSCs-Exos may be conceptualized on the basis of their size, content (cargo), and particularly cellular origin (source) [11]. Exosomes secreted by MSCs of different tissues carry different biological components that confer unique biological roles to the exosomes [18]. BMSCs ...
The ECM of various tissues and organs is composed of the same groups of molecules and, often, the same individual components. The respective concentrations, ratios, and associations of these components are specific to support functions such as tissue homeostasis, differentiation, and repair. Thus, ...
In addition, lnc-PKD2–2-3 was positively correlated with CSC markers in CCA tumor tissues and was markedly upregulated in CCA stem-like cells compared with that in normal CCA cells [140]. Amit K. Srivastava et al. reported that miR-328-3p (miR-328) is significantly upregulated in ...
Memory cells are unique because they remember pathogens and infectious cells faster than others allowing them to fight off bacteria and viruses quickly. Memory T cells are the reason vaccines can create immunities in the body. Applications Each type of T cell can help us to learn about diseases...
tissues and organs will likely differ substantially between different tissues and their resident stem cells. Nonetheless, mounting evidence points to stem cells as an important contributing factor to at least some of the pathophysiological attributes of aging in a number of different tissues. It ...
Like granulocytes, monocytes are produced by stem cells in the bone marrow and circulate through the blood, though in lesser numbers. But, unlike granulocytes, monocytes undergo differentiation, becoming macrophages that settle in many tissues, especially the lymphoid tissues (e.g., spleen and lymph...
PSC derivatives are being developed for therapeutic use in diseases affecting organs and organ systems such as the eye, nervous system, heart, pancreas, liver, intestines, lung, circulatory system and skin, as well as multi-organ and systemic diseases. Human embryonic stem cells (hESCs) and ...
In addition, key ligands that are implicated in HSCR—including GDNF, NRTN and EDN3—were primarily expressed by mesothelium, smooth muscle cells and interstitial cells of Cajal (ICC) (Extended Data Fig. 8h). Formation of secondary lymphoid organs Gut-associated lymphoid tissues and mLN are ...