An object of the present invention is to efficiently establish cells, tissues, and organs capable of serving as donors for treating diseases, without eliciting immune rejection reactions, without starting with an egg cell. This object was achieved by providing a pluripotent stem cell having a ...
Hemolytic disease of newborns also known as erythroblastosis fetalis is when the red blood cells breakdown at a faster rate than they are made. This results in low concentrations of red blood cells in the blood and reduced oxygen-carrying capacity....
1). The Human Lung Cell Atlas (HLCA) comprises data from 486 donors and 49 datasets, including 2.4 million cells, which we re-annotated to generate a consensus cell type reference. The HLCA expands our understanding of the healthy lung and its changes in disease and can be used as a...
Without a way to measure aging, it’s difficult to study the age-related changes in our vital organs, cells and tissues, and the factors that slow down or speed up the aging process, such as inflammation. Fortunately, Anne and her team have come up with a solution. They recently ...
3D bioprinting of tissues and organs. Nat. Biotechnol. 32, 773–785 (2014). Article CAS PubMed Google Scholar Shamir, E. R. & Ewald, A. J. Three-dimensional organotypic culture: experimental models of mammalian biology and disease. Nat. Rev. Mol. Cell Biol. 15, 647–664 (2014). ...
There is a need for in vitro three-dimensional (3D) models based on human cells that integrate external cues, such as those that result from various organ-specific extracellular matrix (ECM) components, soluble signals, mechanical stimulation, and cues from neighboring and distant tissues/organs. ...
However, when these cells were co-treated with iron-chelating agents, the accumulation of ROS and cell death were inhibited. Thus, a new, nonapoptotic, iron-dependent form of cell death was inferred and given the name ferroptosis. The primary instigator of ferroptosis is the iron-dependent ...
Objective To summary the characteristics of adult stem cells and to introduce the definition and the features of stem cell disease.Methods Literature concerning adult stem cells and stem cell disease was extensively reviewed.Results Adult stem cells were localized in tissues and organs, and were able...
Comparable to natural ecosystems (Box3), interactions within tissues and organs generate a complex environment in multicellular organisms. Tumorigenesis has been recognized as an evolutionary process that is driven by the same Darwinian forces that drive the evolution of species in natural ecosystems [53...
(e.g. type 2 diabetes, obesity). Metaflammation is the most convincing mechanism linking nutritional disorders to inflammaging, indicating that the inflammatory milieu of metabolic cells, tissues and organs is altered due to the high nutrient intake8. A pro-inflammatory milieu characterized by high...