Genetically modified cells, tissues, and organs for treating or preventing diseases are disclosed. Also disclosed are methods of making the genetically modified cells and non-human animals. The genetic modification may include a nucleic acid that is transcribed as a human leukocyte antigen G (HLA-G...
Vascular cells of blood vessels and organs across the human body The vascular system has many different functions across the human body beyond its role in oxygen and nutrient transport. We explored vascular cell heterogeneity by integrating single-cell RNA-sequencing data from the Human Cell Atlas ...
In this Review, we discuss recent developments in machine learning algorithms for genome interpretation and for integrative molecular-level modelling of cells, tissues and organs relevant to disease. More specifically, we highlight existing methods and key challenges and opportunities in identifying ...
There is a need for in vitro three-dimensional (3D) models based on human cells that integrate external cues, such as those that result from various organ-specific extracellular matrix (ECM) components, soluble signals, mechanical stimulation, and cues from neighboring and distant tissues/organs. ...
Mononuclear phagocytes (MNPs) encompass dendritic cells, monocytes, and macrophages (MoMac), which exhibit antimicrobial, homeostatic, and immunoregulatory functions. We integrated 178,651 MNPs from 13 tissues across 41 datasets to generate a MNP single-cell RNA compendium (MNP-VERSE), a publicly av...
Yet another group of congenital heart defects affects theaortaand the pulmonary artery. In the complex abnormality known astransposition of the great arteries, theaorta, the greatconduitof blood to the organs and tissues of the body, rises from the right ventricle, which under normal anatomic conf...
without the aid of an optical or acoustical device or instrument肉眼看不到的 Para. 5degenerative: (of illness) marked by gradual deterioration of organs and cells along with loss of function 退行性的breakdown: weakening or collapse of sbs health 衰竭,衰弱congenital: present at birth but not ...
Comparable to natural ecosystems (Box3), interactions within tissues and organs generate a complex environment in multicellular organisms. Tumorigenesis has been recognized as an evolutionary process that is driven by the same Darwinian forces that drive the evolution of species in natural ecosystems [53...
Induced pluripotent stem (iPS) cell-derived 3D cultures enable the generation and study of tissues derived from the somatic cells of a patient. 3D culture is a natural point of integration for fundamental, translational and clinical research. Abstract Mammalian organs are challenging to study as the...
While human single-cell data is limited, the Tabula Muris exists11, which is a powerful resource of scRNA-seq data from mouse including more than 100,000 cells from 20 tissue types (referred in the Tabula Muris resource as organs and tissues). A recent study showed that similar cell types...