Cell therapies have yielded durable clinical benefits for patients with cancer, but the risks associated with the development of therapies from manipulated human cells are understudied. For example, we lack a comprehensive understanding of the mechanisms
10f). Therefore, tactile bristles that lack F-Cells show abnormal mechanotransduction. Fig. 6: Tactile bristles require epidermal F-Cells for touch sensing. a, Left to right: diagram of the adult tactile bristle and the F-Cell, quantifications of the TEP at rest, voltage traces with the ...
Previously, most mouse cyst cells that do not become oocytes were shown to be "nurse cells" since they transfer their cytoplasm andorganellesin a nonsynchronized manner into the pro-oocytes, although their nuclei are excluded (Lei and Spradling, 2016; seeFigure 1B). As predicted, if nearly ...
MuSCs, also known as muscle stem cells, are mainly derived from Pax3+/ Pax7+embryonic progenitor cells [32,33], the typical biomarker on the surface of which is Pax7 [34,35], that plays a key role in maintaining the fixation and proliferation of progenitor cells and preventing early differ...
We focus this report on the nucleus of the lateral olfactory tract (NLOT), a superficial amygdalar nucleus receiving olfactory input. Mixed with its Tbr1-e
Besides activating receptors, NK cells express inhibitory receptors that modulate the strength of activating receptors and contribute to regulating immune responses and tolerance [34]. The CD94/NKG2A (CD94/CD159a) heterodimer and members of the KIR/CD158 family are two distinct classes of HLA-spe...
ILCs are a heterogeneous population of non-T and non-B lymphocytes derived from common lymphoid progenitor cells, and they lack antigen-specific receptors [1]. ILCs are divided into three groups according to their production of signature cytokines, transcription factors that drive their differentiation...
Recent advances in genomics of viruses and cellular life forms have greatly stimulated interest in the origins and evolution of viruses and, for the first time, offer an opportunity for a data-driven exploration of the deepest roots of viruses. Here we b
(AHR). A cytosolic, ligand-dependent basic helix–loop–helix transcription factor that translocates to the nucleus following the binding of specific ligands, which include dietary and microbial metabolites. AHR participates in the differentiation of several T cell subsets, such as regulatory T cells,...
Representative images (l) and SREBP2/DAPI intensity ratio (m) in each cell nucleus of WT and Prkcif/fPrkczf/f;Villin-Cre mouse small intestinal tumors (WT: n = 214 cells from one mouse, Tumor: n = 442 cells from one tumor). n Dot plot of indicated gene signatures against...