Cells experiencing DNA damage undergo a complex response entailing cell-cycle arrest, DNA repair and apoptosis, the relative importance of the three being modulated by the extent of the lesion. The observation that Abl interacts in the nucleus with several proteins involved in different aspects of ...
When surveying the literature, “exosomes” clearly result as the most studied EV population: this phenomenon seems to self-perpetuate leading to the assumption, not supported by current evidence, that they are more important and more interesting than other EV populations [34]. EV cargo: how ...
The organization of the McSC system, responsible for hair pigmentation, is thought to parallel that of hair follicle stem cells (HFSCs)5,6,7,8. McSCs are located in the bulge and hair germ (HG) area in telogen-phase hair follicles (HFs)4,5, where they are surrounded by HF epithelial ...
The present invention relates to bispecific molecules that are capable of localizing an immune effector cell that expresses an activating receptor to a virally infected cell, so as to thereby facilitate the killing of the virally infected cell. In a preferred embodiment, such localization is accompl...
the infection has the potential to result in pneumonia, acute respiratory distress syndrome (ARDS), failure of vital organs, and ultimately, mortality. Certain individuals, such as the older adults and individuals with pre-existing medical conditions, face an increased likelihood of experiencing serious...
Human bone marrow mesenchymal stem cells rescue endothelial cells experiencing chemotherapy stress by mitochondrial transfer via tunneling nanotubes. Stem Cells and Development. 2019;28(10):674–82. Article CAS PubMed Google Scholar Jackson MV, et al. Mitochondrial transfer via tunneling nanotubes is ...
Except for asymptomatic carriers, infection with this virus causes a large fraction of patients to develop moderate clinical illness in a short period, with a small but a substantial number of patients experiencing severe disease characterized by fatal acute lung injury (ALI) and acute respiratory ...
expression; (3) displaying defects in mitochondrial enzyme activity and aging; (4) experiencing disturbances in mitochondrial dynamics and changes in the TCA cycle; (5) initiating mitochondria-mediated apoptosis. Elevated glucose and lactate metabolism in active MS lesions have been revealed through ...
Overall, the interactions of NK cells and T-cells with MHC I are quite similar but yield different outcomes. NK cell interrogation of MHC I creates a tolerance signal that accepts HLA polymorphisms unless HLA is completely missing, very polymorphic, or from another species. This tolerance signal...
Immune cells experience large cell shape changes during environmental patrolling because of the physical constraints that they encounter while migrating through tissues. These cells can adapt to such deformation events using dedicated shape-sensing pathw