The peptides or proteins have an amino acid sequence that is a subsequence of human ficolin and are capable of binding the cells to be sequestered. The pharmaceutical composition can be used in the treatment of connective tissue, and can be used as a dermal filler....
Tendon and ligament injuries are common and costly in terms of surgery and rehabilitation. This might be improved by using tissue engineered constructs to accelerate the repair process; a method used successfully for skin wound healing and cartilage repair. Progress in this field has however been li...
The enzyme compositions are used for dissociating microvessel cells from connective tissue. Recovered microvessel cells are incorporated into artificial vessel grafts. The composition preferrably contains collagenase having an activity of about 43 nkat/ml to about 51 nkat/ml and chymopapin having an ...
Chimeric antigen receptor (CAR) T cell therapy, which targets tumors with high specificity through the recognition of particular antigens, has emerged as one of the most rapidly advancing modalities in immunotherapy, demonstrating substantial success against hematological malignancies. However, previous gene...
The density and complex composition of the ECM can obstruct the migration of CAR-T cells, hindering their ability to reach and infiltrate the tumor core, thus limiting their antitumor activity. The ECM in the TME not only facilitates the growth, invasion, and metastasis of tumor cells but ...
Drugs that selectively kill senescent cells (senolytics) improve the outcomes of cancer, fibrosis and age-related diseases. Despite their potential, our knowledge of the molecular pathways that affect the survival of senescent cells is limited. To discov
None of these cell types expressed the MTJ-B signature. Thus, MTJ-B represents a nuclear population in the myofiber that co-expresses genes typical of the myofiber (e.g. Ttn) and of connective tissue (Pdgfrb, Col6a3, Ebf1). Identification of additional myonuclear populations...
Cells are an essential part of the triple principles of tissue engineering and a crucial component of the engineered ovary as they can induce angiogenesis, synthesize extracellular matrix and influence follicle development. Here, we hypothesize that by c
THE constituents of the extracellular matrix have a fundamental role in the structure and function of all tissues. A major insight into the composition of this matrix came with the discoverythat interstitial collagen was not homogeneous, but rather composed of two species, termed Type I and Type ...
Cell composition deconvolution was conducted utilizing CIBERSORTx [24]. Our initial step was to generate a signature gene expression matrix using the CRC scRNA-seq dataset (GSE178341). We extracted raw count matrix data and cell type classifications from a subset of the Seurat object, which incorp...