Atkins FM,Friedman MM,Subba RPV,et al.Interactions between mast cells, fibroblasts and connective tissue components. International Archives of Allergy and Immunology . 1985Atkins FM, Fridman MM, Subba Rao PV, Metcalfe DD. Inter- actions between mast cells, fibroblasts and connective tissue components...
Of the connective tissue cells, fibroblasts are perhaps the most numerous cells of the body overall. Billions of them inhabit the connective tissue found in all of our organs. A fibroblast has a flattened, dark-staining nucleus and a sparse cytoplasm. They begin their lives in close proximity ...
Furthermore, these cells are held within a capsule of connective tissue, which itself may exhibit rhythmicity. At a cellular level, weak oscillations in clock-dependent transcripts have been observed in both naïve human23 and mouse2 CD4+ T cells. Notably Rev-erbα was found to oscillate in...
There is a complex functional interplay among hematopoietic cells with the supporting connective tissue cells, extracellular matrix, and soluble factors, which form the hematopoietic microenvironment. Behavior of hematopoietic cells is influenced by direct cell-to-cell and cell-matrix interactions and by ...
this tissue forms a communication network. The two properties of a neuron are its excitability and conductivity, both of which enable neurons to react and respond to stimuli. The third tissue type discussed is connective tissue, characterized by its abundant extracellular matrix and composed of fiber...
(CTGF; also known as CCN2) is a member of the CCN family of proteins14,15 which associates with components of the extracellular matrix or cell surface integrins16 and regulates cellular processes such as, adhesion, migration, mitogenesis and differentiation.15 Although CTGF has an important role...
using PCA. The “FindClusters” function was utilized for preliminary clustering and annotation, employing 50 principal components with a resolution of 0.8. The UMAP method was used for nonlinear dimensionality reduction and visualization of cell clustering. Next, a second round of clustering was then...
Both benign and malignant neoplasms are composed of (i) neoplastic cells that form the parenchyma, and (ii) the host-derived non-neoplastic stroma that is composed of connective tissue, blood vessels, and other cells, and supports the tumor parenchyma. The tumor stroma serves a critical function...
connective tissue and mesenchymal stem cells but not immune cells22, and any shared causal variants with NK cell eQTL are likely to be representative of the proportion one would expect by chance (i.e. shared causal loci are likely to represent effects mediated by other cell types)23. We ...
These are embryonic tissues of mesodermal origin, consisting of loosely packed, unspecialized cells set in a gelatinous ground substance, from which connective tissue, bone, cartilage and the circulatory and lymphatic systems develop. Transdifferentiation ...