M. (2016). Stem cells in the adult CNS revealed: examining their regulation by myelin basic protein. Neural Regeneration Research, 11(12), 1916-1917. http://doi.org/10.4103/1673-5374.197127Xu WJ,Lakshman N,Morshead CM.Stem cells in the adult CNS revealed: examining their regulation by ...
Schwann cells that have myelinated the CNS can be replaced by myelinating oligodendrocytes. It is unclear, however, why oligodendrocyte remyelination would occur for axons that are already myelinated. The Schwann cells might signal their own replacement by oligodendrocytes, but more probably a third...
Answer to: Schwann cells form the myelin sheath around multiple axons at once and the neurilemma which aids in axon regeneration after injury. a...
Schwann cells form myelin in the peripheral nervous system. All Schwann cells are surrounded by a basal lamina. Extracellular matrix molecules in the basal lamina, such as laminin, regulate key aspects of Schwann cell development including the formation, architecture and function of myelin. Recent ge...
(AD), mediated by T cells triggered against structural components of myelin and consequent degenerative loss of axon in the central nervous system (CNS). In fact, the nerve atrophy progressively reduces the electrical signalling neurons muscles and related mobility. The inflammatory reaction is an im...
The Soluble Form of LOTUS inhibits Nogo Receptor-Mediated Signaling by Interfering with the Interaction Between Nogo Receptor Type 1 and p75 Neurotrophin R... Nogo receptor type 1 (NgR1) is known to inhibit neuronal regeneration in the CNS. Previously, we have shown that lateral olfactory tract...
In the nervous system, only one type of neuron–glial synapse is known to exist: that between neurons and oligodendrocyte precursor cells (OPCs), yet their composition, assembly, downstream signaling and in vivo functions remain largely unclear. Here, we address these questions using in vivo micr...
et al. MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies. J. Exp. Med. 210, 2921–2937 (2013). This study demonstrates that the antigen-presenting capacity of myelin-specific B cells is required for the induction...
Furthermore, progenitor cells of a more restricted fate have been described, in vitro, to reside within the cerebral cortex and provide a local source of new neurons [4]. Thus, multiple brain areas could function as reservoirs of brain precursor cells. However, the normal CNS environment is ...
Redundant myelin Oligodendrocyte progenitor Plasticity 1. Introduction Traumatic brain injury (TBI) most commonly results from head impact and/or rapidacceleration–deceleration of the head. Within the brain, these forces initiate tissue damage in white matter tracts that is characterized by traumatic axon...