Prerequisites for functional recovery following axonal interruption (i.e. axotomy) in the central (CNS) or peripheral nervous system (PNS) are: 1) Survival of the injured neuron; 2) Axon regrowth of sufficient length to reach its target; 3) Axon guidance and pathfinding such that the appropri...
Furthermore, progenitor cells of a more restricted fate have been described, in vitro, to reside within the cerebral cortex and provide a local source of new neurons [4]. Thus, multiple brain areas could function as reservoirs of brain precursor cells. However, the normal CNS environment is ...
Pro-inflammatory T cells in the central nervous system (CNS) are causally associated with multiple demyelinating and neurodegenerative diseases1,2,3,4,5,6, but the pathways that control these responses remain unclear. Here we define a population of inflammatory group 3 innate lymphoid cells (ILC...
Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila. Curr. Biol. 12, 1293–1300 (2002). Article CAS Google Scholar Rulifson, E. J., Kim, S. K. & Nässel, D. R. Ablation of insulin-producing neurons...
Neural stem and progenitor cells (NSCs) give rise to the cellular diversity of the CNS. There is evidence both for and against differences in these cells based on the region of the brain in which they reside. Primary brain tumors mimic many aspects of NSC behavior. Recent data suggest that...
Increased serum MANF protein levels have been reported in patients with Parkinson’s disease diagnosed on average 6 years ago [19], indicating that circulating MANF levels may be altered in chronic CNS disease. However, we were interested in the potential of MANF in acute diagnostics of stroke...
Furthermore, we outline the inflammatory responses associated with such infections, and discuss the potential role of resident glial cells in the pathogenesis of bacterially induced CNS disorders. 展开 关键词: CNS, bacteria, inflammation, microglia, astrocytes ...
Characterizing the phenotype and understanding the function of ERβ-containing cells in the CNS has been hampered by several factors. First, many of antibodies to ERβ lack specificity or may not recognize all the isoforms of ERβ (Snyder et al., 2010; also see discussion in (Milner et al...
Substantial progress has been made in identifying the extracellular signalling pathways that regulate neural stem and precursor cell biology in the central nervous system (CNS). The bone morphogenetic proteins (BMPs), in particular BMP4, are key players regulating neuronal and glial cell development ...
Therapeutic targeting of senescent cells in the CNS Article 30 September 2024 Lessons from inducible pluripotent stem cell models on neuronal senescence in aging and neurodegeneration Article 01 March 2024 Nintedanib induces senolytic effect via STAT3 inhibition Article Open access 02 September 2022...