近日,来自温州医科大学附属第二医院的研究人员在Cell Death & Disease期刊发表文章,报道了受损的神经元细胞衍生的外泌体会促进脊髓损伤后移植的BMSCs的存活,为脊髓损伤的干细胞治疗提供了理论基础。为了模拟SCI中神经细胞或移植的BMSCs体内微环境,研究人员将PC12细胞的条件培养基以及PC12细胞外泌体在体外H2O2处理的氧化...
Delivering the kiss of death: TNF-related apoptosis-inducing ligands Apart from lytic granules release, NK cells can rely on other weapons namely two TNF-related apoptosis-inducing ligands belonging to the TNF superfamily, TRAIL and FasL (CD95L). Upon binding to their cognate ligands, TRAIL R1...
Cell Death & Disease 5169Accesses 5Altmetric Explore all metrics Abstract The cytidine deaminase, Apolipoprotein B mRNA editing enzyme catalytic subunit 3B (APOBEC3B, herein termed A3B), is a critical mutation driver that induces genomic instability in cancer by catalyzing cytosine-to-thymine (C-to...
Cell Death & Disease5,e1466 (2014)Cite this article 4716Accesses 11Altmetric Metrics Abstract Established as a potent anti-malaria medicine, artemisinin-based drugs have been suggested to have anti-tumour activity in some cancers. Although the mechanism is poorly understood, it has been suggested ...
Adoptive cell therapy of solid tumors with reprogrammed T cells can be considered the “next generation” of cancer hallmarks. CAR-T cells fail to be as effective as in liquid tumors for the inability to reach and survive in the microenvironment surround
Caspase functions in cell death and disease 2013, Cold Spring Harbor Perspectives in Biology Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety 2010, Leukemia View all citing articles on Scopus ...
Cell Death Dis, 10 (2019), p. 957 CrossrefGoogle Scholar 34 N. Kim, P. Lertnimitphun, Y. Jiang, H. Tan, H. Zhou, Y. Lu, et al. Andrographolide inhibits inflammatory responses in LPS-stimulated macrophages and murine acute colitis through activating AMPK Biochem Pharmacol, 170 (2019)...
The presence of CD133-positive CSCs in lung cancer increases the expression of the ABC transporter ABCG2, resulting in lung cancer resistance to first-line drugs such as platinum and paclitaxel. Studies have shown that low-dose platinum therapy can cause DNA damage rather than cell death, ...
Cell Death & Disease volume 9, Article number: 109 (2018) Cite this article 22k Accesses 2 Altmetric Metrics details Abstract Kidney transplantation is the optimal treatment for end-stage renal diseases. Although great improvement has been achieved, immune tolerance is still the Holy Grail that ...
Auranofin (AF), a gold (I)-containing phosphine compound, is being investigated for oncological application as a repurposed drug. We show here that 4~5 µM AF induces paraptosis, a non-apoptotic cell death mode characterized by dilation of the endop