nanovesiclesAlthough T-cell therapy is a remarkable breakthrough in cancer immunotherapy, the therapeutic efficacy is limited for solid tumors. A major cause of the low efficacy is T-cell exhaustion by immunosuppressive mechanisms of solid tumors, which are mainly mediated by programmed death-ligand ...
Cell-Derived Nanovesicles (CDNs) offer a promising alternative to the low yields and lengthy purification steps associated with the exosome production and isolation process. CDNs are obtained by subjecting cells to a physical process resulting in vesicles of nano-dimensions. A variety of methods, i...
Nanovesicles derived from various immune cells, including T cells, macrophages and dendritic cells, have been explored for cancer immunotherapy24,25,26. SCCNVs were produced by serial extrusion of senescence-induced cancer cells (Fig. 1a). Autologous cancer cells for SCCNV preparation would be ...
Cell-derived nanovesicles prepared by membrane extrusion are good substitutes for natural extracellular vesicles Extracellular vesicles (EV) as drug delivery nanocarriers are under intense investigation. Although clinical-grade EVs have been produced on a large-scale,... Y Wen,Q Fu,A Soliwoda,... ...
cell-derived nanovesicles;RNA therapeutics;immunotherapy;biological nanoparticles;targeted delivery Graphical Abstract 1. Introduction Extracellular vesicles (EVs) have shown tremendous promise as targeted therapeutic delivery vehicles in diverse diseases, including cancer [1]. Indeed, large-scale biomanufacturing...
Keywords: extracellular vesicles;biofabrication;cell-derived nanovesicles;therapeutic delivery;regenerative medicine Graphical Abstract
Nanovesicles Diabetic wounds 1. Introduction Diabetic wounds are severe complications of diabetes mellitus that usually heal slowly and become infected, leading to disability, limb amputation, and even mortality[1]. The complications associated with diabetic wound healing stem from a hypoxic and chronic ...
来源期刊 Nanomedicine 研究点推荐 Cell membrane-derived nanoparticles nanotechnology targeted drug delivery nanomedicine Biofunctionalization of nanoparticles cell-derived nanovesicles 引用走势 2018 被引量:3 0关于我们 百度学术集成海量学术资源,融合人工智能、深度学习、大数据分析等技术,为科研工作者提供全面快捷的...
These nanovesicles were specifically designed to target macrophages in ischemic myocardium for the treatment of myocardial ischemia-reperfusion (IR) injury. Through targeted delivery dextran, ApoNVs effectively reduce the inflammatory response and promote the polarization of M2 macrophages during the early ...
Nanovesicles have also been found in edible-plants and have shown therapeutic activity in inflammatory bowel diseases; however information on their role in affecting cancer progression is missing. Our study identify for the first time a fraction of vesicles from lemon juice (Citrus limonL.), ...