Herein, T-cell-derived nanovesicles (TCNVs) produced by the serial extrusion of cytotoxic T cells through membranes with micro-/nanosized pores that inhibit T-cell exhaustion and exhibit antitumoral activity maintained in the immunosuppressive tumor microenvironment (TME) are presented. TCNVs, which ...
Cell Derived Nanovesicles were labelled with cyanine 5.5N-hydroxysuccinimide (NHS) monoester by adding the dye as per manufacturer instructions at pH 8 and incubating for 4 hours on ice. The labelled CDNs were then returned to pH 7 and free dye was removed by overnight dialysis in PBS, b...
Tumor lysates, which may have a similar composition to cancer cell-derived nanovesicles, can also be used as a potential TCV to deliver tumor antigens. However, tumor lysate vaccination generally results in low-efficiency DC activation and, in turn, weak antitumor immunity43. In contrast, SCCNVs...
近年来,研究发现间充质干细胞(Mesenchymal stem cells, MSC)及其来源的细胞外囊泡(MSC-derived extracellular vesicles, MSC-EVs)具有高效的促损伤修复和组织再生功效,其可以显著改善PH引起的血管重构和右心功能障碍。然而,MSC-EVs的...
Cell-derived nanovesicles prepared by membrane extrusion are good substitutes for natural extracellular vesicles Extracellular vesicles (EV) as drug delivery nanocarriers are under intense investigation. Although clinical-grade EVs have been produced on a large-scale,... Y Wen,Q Fu,A Soliwoda,... ...
2.11. Preparation of BMSC-derived nanovesicles (NV) The NV was prepared with a serial extrusive approach[23],[34]. More detailed procedures can be found in theSupplementary Materials and Methods. 2.12. Tem The morphology of the NV was observed using TEM. First, NV was dispersed in 2% parafo...
来源期刊 Nanomedicine 研究点推荐 Cell membrane-derived nanoparticles nanotechnology targeted drug delivery nanomedicine Biofunctionalization of nanoparticles cell-derived nanovesicles 引用走势 2018 被引量:3 0关于我们 百度学术集成海量学术资源,融合人工智能、深度学习、大数据分析等技术,为科研工作者提供全面快捷的...
IntroductionWe have recently demonstrated that Citrus-limon derived nanovesicles are able to decrease colon cancer cell viability and that this effect is a... S Raimondo,M Cristaldi,S Fontana,... - 《Journal of Experimental & Clinical Cancer Research》 被引量: 0发表: 2018年 Exosome-like Nanov...
[231]. Another research carried out by Farinazzo linked the decreased activity of CNS immune cells including microglial and T cell extravasation with reduced demyelination in the spinal cord after treatment by nanovesicles secreted from adipose stem cells (ASC) [232]. Due to exosome’s ability to...
p>Naturally derived nanovesicles secreted from various cell types and found in body fluids can provide effective platforms for the delivery of various cargoes because of their intrinsic ability to be internalized for intercellular signal transmission and membrane recycling. In this study, the versatility...