研究发现,在低质量胚胎中,ATP合成相关蛋白(如ATP5A1、NDUFA9)的表达显著降低,提示这些胚胎可能因能量供应不足而无法正常生长。 氧化应激(oxidative stress)也是胚胎发育失败的重要因素。该研究发现,过氧化物还原酶1(PRDX1)在低质量胚胎中的...
Video S1. Time-Lapse Phase Contrast Imaging MCF10A Acini in 3D Cultures at Day 4 after Treatment with CM Collected from MCF10A Cells with Normal Centrosome Number (−DOX), Related to Figure 1 Video S2. Time-Lapse Phase Contrast Imaging MCF10A Acini in 3D Cultures at Day 4 after Treatmen...
摘要：Aging, as a complex process involving multiple cellular and molecular pathways, is known to be exacerbated by various stresses. Because responses to these stresses, such as oxidative stress and genotoxic stress, are known to interplay with the epigenome and thereby contribute to the development...
Oxidative stress acts as a potent catalyst in the transformation of normal cells into cancerous phenotypes, primarily by compromising genomic integrity. Elevated levels of reactive oxygen species (ROS), a hallmark of oxidative stress, interact with cellular macromolecules like DNA, RNA, and proteins. ...
Characterization of the Electrochemical Oxidation of Peroxynitrite: Relevance to Oxidative Stress Bursts Measured at the Single Cell Level M.; Vuillaume, M., Characterization of the electrochemical oxidation of peroxynitrite: relevance to oxidative stress bursts measured at the single cell level... Christi...
Deficiencies of these enzymes increase oxidative stress and NO inactivation and, as such, can either lead to ECD or account for the underlying mechanism of ECD associated with a given atherothrombotic risk factor. Selected antioxidants improve intracellular redox state and reverse ECD by improving the...
Next, we tested the chemotactic migration of CD8+ T cells from patients with vitiligo mediated by the CXCL16-CXCR6 pair using the transwell assay. Results CXCL16 expression increased and showed a positive correlation with oxidative stress levels in serum and lesions of patients with vitiligo. The...
The data presented in this paper show in a novel way how storage under short-term oxidative stress modifies the cell wall of apple fruit at the molecular level.Similar content being viewed by others Impact of different storage conditions with combined use of ethylene blocker on ‘Shalimar’ ...
Cells are continuously exposed to various stress factors that endanger their functionality and thus, their ability to cope with stress. The ability of cells to adapt and survive by restoring homeostasis is an integral component of cellular physiology. However, if the stress is persistent and homeosta...
In addition, oxidative stress has been shown to result in inhibition of the Ca2+-ATPase pump in red blood cells [88] and the activation of Ca2+-permeable unselective cation channels with subsequent increase in intracellular Ca2+ (Fig. 1A) [60]. This leads to activation of calpain, ...