We observed distinct transcriptional contributions from solid tissue-specific cell types from the intestine, liver, lungs, pancreas, heart, and kidney (Fig. 1d and Extended Data Fig. 4). Altogether, the observation of contributions from many non-hematopoietic cell types underscores the ability to ...
Relatively little is known about the protein composition of the different regions and cell types of the heart. Previous studies have focused on defining differences between specific regions of the heart, or single-diseased heart compartments5, or from nonhuman, or subcellular material6,7. Phosphoprote...
Infections with mycoplasma that can change the culture properties, Difficulty in the establishment of long‐term cancer cell lines of certain types of tumors, Cell culture environment is different from that of the original tumor, Loss of the natural heterogeneity of the tumor or tissue [77, 78]...
The reduction in white blood - cell counts lowers resistance to disease. 白细胞计数减少会降低对疾病的抵抗力. 互联网 展开全部 英英释义 Noun 1. either of two types of cells (erythrocytes and leukocytes) and sometimes including platelets 行业词典 ...
Microvesicles (MV) derived from activated cells vary by cell of origin and the stimulus initiating their release. MV released from cells activated by inflammatory and thrombotic factors have the potential to disrupt endothelial cells of the brain microvasculature. Therefore, experiments were designed to...
Human embryonic stem cells, derived from the early human embryos, and human-induced pluripotent stem cells, derived by reprogramming somatic cells (hESCs and hiPSCs, respectively, and collectively called hPSCs) can self-renew and differentiate into all cell types of the human body, including cardiomy...
The heterogeneity of these practolol inhibition curves indicated that both types of beta-adrenergic receptors are coupled to the cyclase. Analysis of the dose-response curves of adenylate cyclase activation obtained with specific beta2-agonists also showed a heterogeneity of the response. This finding ...
Third, because of the lack of targeting, these Exo may also be absorbed by other cell types of the heart, leading to extra-target effects. Gene or chemical modification of extracellular vesicles may be an effective way to solve this problem. Finally, the identification of the origin of ...
Owing to the prevalence and high mortality rates of cardiac diseases, a more detailed characterization of the human heart is necessary; however, this has been largely impeded by the cellular diversity of cardiac tissue and limited access to samples. Here, we show transcriptome profiling of 21,422...
Pluripotent stem cells have the ability to differentiate into any cell types that make up the body. They are typically found during the earliest stages of cell division after fertilization. As a result, scientists are trying to harness the regenerative potential of stem cells to treat many challen...