Solving a longstanding mystery, scientists have found that the human heart continues to generate new cardiac cells throughout the life span, although the rate of new cell production slows with age. The finding, published in the April 3 issue of Science, could open a new path for the treatment...
Breast Cancer Drug Neratinib Found to Protect Against Atherosclerosis American Heart Month Atherosclerosis is a common disease that develops when the buildup of fats, cholesterol and other substances in and on the artery walls. This buildup—called plaque—can cause arteries to narrow, blocking blood...
Diabetes, a group of metabolic disorders, constitutes an important global health problem. Diabetes and its complications place a heavy financial strain on both patients and the global healthcare establishment. The lack of effective treatments contributes
Stem cell models of organogenesis are a valuable tool for the study of human development, but often lack the context of tissue-tissue interaction. Here they generate human multi-lineage organoids comprising pro-epicardium, septum transversum, and liver bud, which they co-culture with heart organoi...
(C) ELISA assay of xanthine in the different organs of WT and Miga2TKO mice are presented as relative fold to those in the heart of Miga2TKO mice (n = 4). (D) Rag1−/− mice were i.v. adoptively transferred with 5 × 106 CD4+ or CD8+ T cells isolated from NT or ES-...
In this study, the researchers generated heart cells from donated skin cells, via an intermediary cell type called an induced pluripotent stem cell (iPSC). Then they grew these iPSC-derived heart cells on a graphene surface. They have found that cells in the lab grow better on graphene than...
As a powerful natural antioxidant, melatonin also exhibits anti-fibrosis effects in the heart, liver, lung, and kidney, as well as other organs [[44], [45], [46], [47], [48]]. Actually, due to its ability to reduce oxidative stress, several studies have also demonstrated that ...
The relative roles of different types of T cells and their modes of alloantigen recognition and cytokine production in chronic rejection have been controversial. This may be due to the use of models involving various immune interventions. We recently reported a rat heart allograft model (PVG.1U-...
Kandel's team found in a previous study that CPEB3 plays a critical role in strengthening synapses, the connection points where tiny branches of neurons connect to each other when all memories are made. When they prevented mice from making CPEB3, those animals could form a new memory but ...
This was associated with increased expression of stromal cell-derived factor 1 alpha (SDF1α), and a significant positive correlation was found between c-Kit+ CSCs and SDF1α expression in the heart. Moreover, the migratory capacity of isolated c-Kit+ CSCs was induced by SDF1 treatment in ...