To date, most expression quantitative trait loci (eQTL) studies, which investigate how genetic variants contribute to gene expression, have been performed in heterogeneous brain tissues rather than specific cell types. In this study, we performed an eQTL
Cell‐type specific eQTLs (ct‐eQTLs) associated with Alzheimer disease in blood and brain tissueExpression quantitative trait locus(eQTL) analysis has demonstrated that changes in gene expression play a role in Alzheimer disease(AD) pathogenesis. Regulation of gene expression is dependent on context ...
but also identified new celltype-specific cis-eQTLs. Finally, we generated personalized co-expression networks and identified genetic variants that significantly alter co-expression relationships (which we termed ‘co-expression QTLs’). Single-cell eQTL analysis thus allows for the identification of gen...
A new study reports the mapping of in primary immune subsets, showing the presence of type-specific cis and trans expression quantitative trait loci (eQTLs). The identification of type-specific trans-regulated networks can inform functional studies of susceptibility loci identified from genome-wide ass...
Single-cell RNA sequencing identifies celltype-specific cis-eQTLs and co-expression QTLs. Nat Genet. 2018;50(4):493–7. Article PubMed PubMed Central Google Scholar Nathan A, Asgari S, Ishigaki K, Valencia C, Amariuta T, Luo Y, et al. Single-cell eQTL models reveal dynamic T cell ...
Single-cell RNA sequencing identifies celltype-specific cis-eQTLs and co-expression QTLs. Nat Genet. 2018;50(4):493–7. Article PubMed PubMed Central Google Scholar Nathan A, Asgari S, Ishigaki K, Valencia C, Amariuta T, Luo Y, et al. Single-cell eQTL models reveal dynamic T cell ...
Single-cell RNA sequencing identifies cell-type-specific cis-eQTLs and coexpression QTLs. Nat. Genet. 50, 493–497 (2018). This study used single-cell eQTL analysis to uncover genetic variations that influence regulatory networks by producing expression profiles of 25,000 PBMCs from 45 donors ...
(HBI) model to infer cell-type-specific meQTLs, which integrates a large-scale bulk methylation data and a small-scale cell-type-specific methylation data. Through simulations, we show that HBI enhances the estimation of cell-type-specific meQTLs. In real data analyses, we demonstrate that ...
integrative multi-omics single-nucleus framework studies profiling chromatin accessibility and gene expression [43,44] identified cell type-specific, disease-associated candidatecis-regulatory elements (cCREs) and their candidate target genes, and demonstrated the utility and potential of this strategy in ...
The genetic control of gene expression is highly cell-type specific We tested for cis-eQTL for each cell population independently and identified a total of 4,443 eQTL that surpassed the study-wide significance threshold of FDR < 0.05 (Benjamini-Hochberg procedure), and the eGene was expressed ...