近日,使用单核RNA测序技术,Dheeraj Malhotra和Julien Bryois团队对192个,分别来自前额皮质、颞皮质和白质的8种脑细胞类型个体进行eQTL分析,并将他们最新的结果发表于Nature Neuroscience杂志上,“Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological...
神经元cis-eQTL的复制率略高于胶质细胞cis-eQTL(图2c),可能是因为胶质细胞细胞类型不如皮层中的神经元普遍。cis-eQTLs在TSS(转录起始位点)周围富集(图2d),并且在基因上游或基因体内比基因下游更常见。仅在神经元细胞类型中检测到的cis...
We identified 113,374 cis-eQTLs for 12,266 genes, a substantial fraction 39.1% of which were discovered in at least two tissues. The cis-eQTLs of blood were less conserved across tissues, while cis-eQTLs from any tissue exhibit a strong sharing pattern to liver tissue. Colocalization between...
eQTLs using an unbiased approach, we used single-cell RNA sequencing to generate expression profiles of ~25,000 peripheral blood mononuclear cells from 45 donors. We identified previously reported cis-eQTLs, but also identified new celltype-specific cis-eQTLs. Finally, we generated personalized co-...
Bryois, J., Calini, D., Macnair, W.et al.Cell-type-specificcis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders.Nat Neurosci25, 1104–1112 (2022). https://doi.org/10.1038/s41593-022-01128-z ...
We validated this approach by replicating previously published whole blood RNA-seq cis- expression quantitative trait loci effects ( cis- eQTLs), but also identified new cell type-specific cis- eQTLs. These eQTLs give additional insight into the downstream consequences of genetic risk factors for ...
(2.85%) of the QTL peaks obtained from the SNP-free probes of the SNP-containing probe sets are cis-eQTLs while a much larger proportion of the eQTL peaks (up to 30%) obtained from the SNP-containing probes in the same probe sets are cis-eQTL peaks, especially from the probes with ...
To identify these celltype-specific eQTLs using an unbiased approach, we used single-cell RNA sequencing to generate expression profiles of ~25,000 peripheral blood mononuclear cells from 45 donors. We identified previously reported cis-eQTLs, but also identified new celltype-specific cis-eQTLs. ...
Top high-confidence treatment specific cis-eQTLs.Elin, GrundbergVéronique, AdoueTony, KwanBing, GeQing, Ling DuanKevin, C. L. LamVonda, KokaAndreas, KindmarkScott, T. WeissKelan, Tantisira
bind testing metadata to a best.cis.eQTLs resultsmpackvec