Impact of tissue factor expression and administration routes on thrombosis development induced by mesenchymal stem/stromal cell infusions: re-evaluating the dogma Van T. Hoang, Duc Son Le, Duc M. Hoang, Trang Thi Kieu Phan, Lan Anh Thi Ngo, Trung Kien Nguyen, Viet Anh Bui & Liem...
The natural processes of bone repair are sufficient to restore skeletal integrity for most fractures. However, there are cases of fracture healing in which bone regeneration is impaired or required in large quantities. Recently, tissue engineering has be
Tissue factor (TF) is a membrane protein that regulates the extrinsic coagulation system4. In this system, TF forms a TF/FVIIa complex that activates FIX and FX to FIXa and FXa, respectively. FXa activates prothrombin to thrombin, which in turn polymerizes fibrinogen to form fibrin4. TF-de...
Each batch of human CMs was generated from the same working cell bank material. CMs expressed cardiac troponin T (CTNT) and had evidence of cytoskeletal formation (Extended Data Fig.1d,e). Genes for pluripotency, early mesoderm induction and cardiac specification were assessed via quantitative poly...
Furthermore, the transcription factors whose binding sites are perturbed by genetic variants tend to have higher expression levels in the cell types where the variants exert their effects, compared to the cell types where the variants have no impact. We further validate our findings with high-...
2.2. GMP Manufacturing of SLCTmsc02–Umbilical Cord Tissue MSCs The starting material for SLCTmsc02 is an umbilical cord tissue cell suspension cryopreserved at Stemlab S.A. cell bank (Cantanhede, Portugal). The Cryopreservation Laboratory of Stemlab S.A. (Cantanhede, Portugal) is a facility th...
Human mesenchymal stem cells: A bank perspective on the isolation, characterization and potential of alternative sources for the regeneration of musculoskeletal tissues. J. Cell Physiol. 2013, 228, 680–687. [Google Scholar] [CrossRef] Vinatier, C.; Guicheux, J. Cartilage tissue engineering: ...
DVC Stem sources its cells from its partner lab Vitro Biopharma Inc, a state of the art, US-based, FDA registered, cGMP compliant and ISO 9001 certified laboratory, and only use American Association of Tissue Bank (AATB) certified suppliers of full-term, ethically U.S.-donated human umbilica...
This strategy depends on the ability to harvest and expand cells to numbers sufficient to replace damaged tissue, or for the cells to proliferate to the required number after transplantation, and for the transplanted cells to develop into new tissue that becomes integrated with the surrounding ...
In these models, cell lines, or cells isolated from tumors or tumor tissue, are implanted in a recipient animal. Both human and murinecan be employed. Implantation can be achieved by subcapsular liver injection or byof cells, which are then carried to the liver through the. In this model,...