This theory of “free cell formation” was rejected by scientists of that time—Robert Remark, Rudolf Virchow, Albert Kölliker [3]. A year later, Schwann examined animal tissues and also observed that “the elementary parts of all tissues are formed from cells” and that “there is one ...
CellRank probabilities for acquiring the terminal delta cell fate. Cells are colored by the probability of reaching the delta state. Inset, group of cells likely to become delta, showing differentiation path predicted by CellRank. Fev+
We present Building Aggregates with a Neighborhood Kernel and Spatial Yardstick (BANKSY), an algorithm that unifies these two spatial clustering problems by embedding cells in a product space of their own and the local neighborhood transcriptome, representing cell state and microenvironment, respectively...
(Fig.2C-D). Moreover, a stable POSTN-overexpressed cell line was established using H446 cells (Fig.2E-F). As revealed by various functional assays in vitro, POSTN-overexpression enhanced the malignant properties of SCLC, encompassing enhanced cell proliferation, migration, and invasion (Fig.2G-...
rejected Weismann’s theory and he did experiments on tadpoles which gave him two ideas on his book on regeneration: First, regeneration is a natural process related to normal development and differentiation. Second, cell fate is not predetermined by heredity or bythe cell’s position in the ...
this made my ears perk up. The blood-cerebrospinal fluid barrier’s abnormal functions in the choroid plexus of the brainis seen in some Lupus patients with neuropsychiatric symptoms. The theory is that post-viral or general permeability of these barriers is part of why neuropsychiatric symptoms ...
(SCLC) was indicative of treatment failure and poor overall survival [96]. Huang et al. and Wang et al. also contributed to this theory when they showed that higher rates of occurrence and poorer overall survival of patients with locally advance breast cancer patients and ovarian serous ...
Subsequently, we use strategies based on the network control theory with nonlinear dynamics to model the cell fate dynamics at the gene level, following the assumption of the Waddington landscape31, stating that each cell fate acts as an attractor, in which the dynamics are mainly determined by ...
function (MF). Bubble size represents the number of genes in each GO term, and gray shadows indicate insignificant GO terms. The enrichment analysis was performed using two-tailed Fisher’s exact test, withp-values adjusted for multiple testing using the Benjamini-Hochberg false discovery rate (...
With 23 chromosomes to choose from, each human, for example, could in theory produce 223—or ___—genetically distinct gametes. 内容已经隐藏,点击付费后查看 Patients with albinism type II (an autosomal recessive disorder) have white hair, white skin, and pupils that look pink because a lack o...