This theory was disproved by the Italian naturalist Lazzaro Spallanzani (1729–1799) in the mid‐eighteenth century. In his masterful experiments, he showed that an organism was derived from another living organism(s), and he confirmed that there was a gap between inaminate matter and living or...
remote organs is important, in particular at early stages of lung disease. Interestingly, obesity is associated with prolonged survival in IPF patients (Alakhras et al., 2007), suggesting that WAT-derived factors may have beneficiary effects. These factors could in theory correspond to the ...
In the present study, we describe SnapATAC2 for the analysis of a diverse array of single-cell omics data. The performance of SnapATAC2 exceeds that of existing dimensionality reduction methods in terms of accuracy, noise robustness and scalability, thus providing researchers with a powerful tool f...
The primary objective of scAGDE is to revolutionize the analysis of high-dimensional sparse scATAC-seq data by learning low-dimensional topological embedding representations. The summary of scAGDE is shown in Fig.1a, which mainly consists of processing scATAC-seq data using a chromatin accessibility-...
researchers can identify cell types or cell type subgroups within the gene expression data. In the clustering task, we now support 5 models. The first 3 models are GNN based, and the later 2 models are non-GNN based with AE as the backbone. The clustering performance is evaluated by ARI....
The theory that the nucleus also arose via endosymbiosis was first proposed in a classic 1905 paper by Mereschkowsky[8]. There, in an insight that was many decades ahead of its time, the author proposed that a bacterium was “invaded by small micrococci which lived as symbionts and ultimat...
Characterizing the behaviors of dynamic systems requires capturing them with high temporal and spatial resolution. Owing to its transparency and genetic tractability, the Arabidopsis thaliana root lends itself well to live imaging when combined with cell
infection. Traditionally, as non-inflammatory but programmed cell death, apoptosis is crucial in protecting the host from microbial infection without eliciting an excess inflammatory response. However, the recent progress of necroptosis has greatly drawn the researchers’ attention to study host–pathogen ...
Identifying relevant disease modules such as target cell types is a significant step for studying diseases. High-throughput single-cell RNA-Seq (scRNA-seq) technologies have advanced in recent years, enabling researchers to investigate cells individually
In theory, one can develop a new MMSE estimator for the scenario simulated here, which will be optimal in terms of NMSE if the same side information learned by ML-based methods is available. However, this prior information may be hard to describe mathematically and must be extracted from the...