This theory was disproved by the Italian naturalist Lazzaro Spallanzani (1729–1799) in the mid‐eighteenth century. In his masterful experiments, he showed that an organism was derived from another living organism(s), and he confirmed that there was a gap between inaminate matter and living or...
we propose the use of SDE-informed RNA velocity, SDEvelo, which collaboratively estimates multivariate RNA velocity across multiple genes governed by a cell-specific latent time, accounts for the inherent stochastic nature of kinetics during the transcription...
Virchow’s cell theory was introduced to neuroscience by Cajal, whose ‘neuron doctrine’ postulated that the structural unit of the nervous system was the individual neuron2. Since then, generations of investigators have described hundreds of cell types in nervous systems of different species. This...
POSTN directly binds to membrane receptor NOTCH1 to promote the activation of hepatic stellate cells.ASchematic diagram of POSTN and NOTCH1 truncations;B-CCo-IP was used to analyze the interaction between POSTN and full-length NOTCH1 (B) or NOTCH1-NECD domain (C) in 293T cells;DPull down...
According to the idea of the differentiation theory, it implies that both errors in the genetic program and DNA replication are at least moderately affected by exogenous factors. Age-related alterations of the lymphohematopoietic system, particularly of its lymphoid part, are well reported. However,...
rejected Weismann’s theory and he did experiments on tadpoles which gave him two ideas on his book on regeneration: First, regeneration is a natural process related to normal development and differentiation. Second, cell fate is not predetermined by heredity or bythe cell’s position in the ...
this made my ears perk up. The blood-cerebrospinal fluid barrier’s abnormal functions in the choroid plexus of the brainis seen in some Lupus patients with neuropsychiatric symptoms. The theory is that post-viral or general permeability of these barriers is part of why neuropsychiatric symptoms ...
In its simplest and qualitative form, theory predicts that neutral macromolecular crowders, i.e. globular macromolecules that do not interact with the protein examined, should increase the population of the folded species over that of the unfolded species because the latter is supposed to occupy a...
infection. Traditionally, as non-inflammatory but programmed cell death, apoptosis is crucial in protecting the host from microbial infection without eliciting an excess inflammatory response. However, the recent progress of necroptosis has greatly drawn the researchers’ attention to study host–pathogen ...
Based on the above characteristics of EPCs, in theory, as long as it is a method that can protect the number and function of EPCs, it may become a treatment for diabetic vascular disease (Fig.3). A study found that the mobilization of EPCs to vascular injury in type 1 diabetic rats w...