Frankel,Jen-Sing Liu.Antibody Internalization after Cell Surface Antigen Binding is Critical for Immunotoxin Development.Bioconjugate Chemistry. 2009Antibody Internalization after Cell Surface Antigen Binding is Critical for Immunotoxin Development. Shu-Ru Kuo,R,all W. Alfano,Arthur E. Frankel,Jen-Sing ...
Uptake of each peptide was linearly dependent on its cell surface binding, and affinity is thus important for efficiency. However, the gradients of these linear dependencies varied significantly. Thus each peptide's ability to stimulate uptake once bound to the cell surface is reliant on formation ...
6). Notch is a cell surface protein that contains an extracellular ligand-binding domain, a single transmembrane-spanning segment, and an intracellular domain capable of binding and activating nuclear transcriptional factors (reviewed in Fortini [43]). The Notch ligands, such as Jagged, are als...
Staining cell surface targets protocols Protocol A: Cell Suspensions Protocol B: Human Lysed Whole Blood General notes For optimal performance of fluorochrome conjugated antibodies, store vials at 2–8°C in the dark. Do not freeze. Prior to use, quick spin the an...
3f). In contrast, isotype-matched antibodies targeting the plasma membrane receptor RANK at the surface of osteoclasts had no effect despite comparable levels of binding between α-La mAb and α-RANK antibody to the surface of synchronized cells following LPC removal (Fig. S5a). While RANKL-...
Distribution and force spectroscopy of CD20 antigen-antibody binding on the B cell surfaceB 细胞膜CD20 抗原的分布与单分子力谱探测Distribution and force spectroscopy of CD20 antigen-antibody binding on the B cell surfaceB 细胞膜CD20 抗原的分布与单分子力谱探测B-CLL外周...
The 10% of beads that showed periodic adhesion patterns are likely the result of bead aggregation during antibody incubation, resulting in uneven surface coating. To confirm that a random spatial distribution of microvilli on the cell surface is not responsible for the observed large asymmetry, we ...
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A human monoclonal antibody specifically binding to a surface antigen of cancer cell membrane, an isolated DNA encoding the antibody, and a hybridoma producing the antibody. An anti-cancer formulation comprising the monoclonal antibody bonded to the surface of a liposome enclosing an anti-cancer agent...
A human monoclonal antibody specifically binding to a surface antigen of cancer cell membrane, an isolated DNA encoding the antibody, and a hybridoma producing the antibody. An anti-cancer formulation comprising the monoclonal antibody bonded to the surface of a liposome enclosing an anti-cancer agent...