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9401S Phospho-c-Myc (Thr58/Ser62) Antibody, 100 ul KIT Cell Signaling(CST) 9402S c-Myc Antibody, 100 ul KIT Cell Signaling(CST) 9405S N-Myc Antibody, 100 ul KIT Cell Signaling(CST) 9407S DDX6/RCK Antibody, 100 ul KIT Cell Signaling(CST) 9411S Phospho-Tyrosine Mouse mAb (...
3262S Blk Antibody, 100 ul KIT Cell Signaling(CST) 3263S eIF6 Antibody, 100 ul KIT Cell Signaling(CST) 3264P Ero1-Lx Antibody, 40 ul KIT Cell Signaling(CST) 3264S Ero1-Lx Antibody, 100 ul KIT Cell Signaling(CST) 3265S EGF Receptor (V279) Antibody, 100 ul KIT Cell Signaling...
A hallmark of tumor cells, including bladder cancer (BLCA) cells, is metabolic reprogramming toward aerobic glycolysis (Warburg effect). The classical oncogene MYC, which is crucial in regulating glycolysis, is amplified and activated in BLCA. However, d
While not possessing kinase domains, integrin receptors can activate a number of intracellular signaling pathways and targets following ECM adhesive interactions: Αctinin GRB7 Ras Caveolins JNK SAPK cMyc Jun SFD Collagen MAPK Shc Crk MEK SOS DOCK180 MEKK Src Elk1 p...
et al. Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis. Cancer Cell 22, 167–179 (2012). Article PubMed PubMed Central CAS Google Scholar Varano, G. et al. The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition. Nature 546, 302–306 ...
T 细胞衍生的信号强度与 B 细胞受体亲和力以及随后的 Myc 表达量成正比。然而,由于 Myc mRNA 及其相应蛋白寿命非常短,目前尚不清楚 T 细胞如何在阳性选择的 B 细胞中诱导持续的 Myc 水平。本研究发现Myc 上调反映了转录活性随时间的整合,而不是转录物在特定时间点的积累。
Chromatin was cross-linked in 1% formaldehyde for 10 min at 37°C, sonicated to sizes of 200–1000 bp, followed by incubation with 3 μg of magnetic beads coated with anti-c-MYC and anti-IgG antibody (Millipore) overnight at 4°C for 2 h. Then protein/DNA complexes were ...
Continuous cancer growth is driven by subsets of self-renewing malignant cells. Targeting of uncontrolled self-renewal through inhibition of stem cell-related signaling pathways has proven challenging. Here, we show that cancer cells can be selectively d
(H) ChIP assays were performed using anti-c-Myc antibody or rabbit immunoglobulin G (IgG). The promoter regions of ornithine decarboxylase (ODC) and nucleoplasmin (NPM) were used as positive controls. The promoter region of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) was used as a negative...